Organic Synthesis on Solid Phase
Supports, Linkers, Reactions
by F. Zaragoza Dörwald
Novo Nordisk A/S
Wiley-VCH, March 2000
ISBN 3-527-29950-5
474 pages, approx. $ 135.-
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Keywords: combinatorial chemistry, compound
libraries, parallel synthesis, organic synthesis, combinatorial techniques,
drug discovery, small molecule libraries, peptides, oligonucleotides,
oligosaccharides, polymers, compound arrays, high throughput screening,
automated compound production
Table of contents:
1. General Techniques and Analytical Tools for Solid-Phase Organic
Synthesis
2. Supports for Solid-Phase Organic Synthesis
3. Linkers for Solid-Phase Organic Synthesis
4. Preparation of Organometallic Compounds
5. Preparation of Hydrocarbons
6. Preparation of Alkyl and Aryl Halides
7. Preparation of Alcohols and Ethers
8. Preparation of Sulfur Compounds
9. Preparation of Organoselenium Compounds
10. Preparation of Nitrogen Compounds
11. Preparation of Phosphorus Compounds
12. Preparation of Aldehydes and Ketones
13. Preparation of Carboxylic Acid Derivatives
14. Preparation of Carbonic Acid Derivatives
15. Preparation of Heterocycles
16. Preparation of Oligomeric Compounds
17. Index
Organic synthesis on insoluble supports is a rapidly developing methodology
which offers several advantages if compared to traditional synthesis in
solution. In recent years many new synthetic methods for solid-phase synthesis
have been developed, and this technique is becoming a valuable alternative to
traditional synthesis, in particular when large numbers of different compounds
in small quantities are needed for screening. Combinatorial chemistry and the
production of compound libraries are usually based on solid phase synthesis.
This exhaustive and systematically organized reference, written by a
chemist for chemists, gives an in-depth view on solid-phase organic synthesis.
The work quickly guides the reader to the best method for preparing a given
class of compounds on solid phase. Many tables with numerous examples
illustrate the feasibility of a given reaction on insoluble supports, and all
the information can be easily located either using the table of contents or the
(very extensive) index.
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