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In Illinois, Federal Route 40 is an east-west route in the southern part of the state with a slight northeast-southwest tilt. Following very closely along Interstate 70, it enters the state at St. Louis, Missouri, and exits near Terre Haute, Indiana.

Information on US40 is broken down into 3 parts:

Missouri state line to Madison/Bond County line(includes Metro-East)

Madison/Bond County line to Effingham/Fayette County line (includes Vandalia)

Effingham/Fayette County line to Indiana state line (includes Effingham)

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