Spike's Love Connections
- Cecily (unrequited love of his human life)- Before Spike was a vampire, he was a human named William. A poet living in England, writing poems about his big crush called Cecily. However she didn't express the same feelings and bluntly told him that he was beneath her and that's where it ended.
- Drusilla (their love was eternal until she dumped him)- After Cecily crumbled William, Drusilla was there to lend a helping hand a wipe the tears away, and made Spike. Spike and Drusilla were an instant couple. Spike was drawn to Drusilla's mad and insane ways. They were together for 100 years, maybe more, but upon Angel turning into Angelus in Sunnydale, Spike found he had some competition. But Spike still got his girl and fled out of Sunnydale to Brazil. There Drusilla began to cheat on him and this sent the miserable Spike back to Sunnydale, but there he realized the only way to get her back was to be the man that he's always been and returned to her. But again things didn't last and Spike found himself back in Sunnydale.
- Harmony (rebound girl)- No idea how this happened, but Spike and Harmony found each other and were together for quite a while considering the ups and downs the couple had. They had a very rocky relationship, if you can call it a relationship, with Spike saying that he loved syphilis more than her. But in the end Harmony walked away, on numerous occasions, not affecting Spike that much in anyway.
- Buffy Summers (loves her, shags her, but can never really have her)- Spike suddenly found himself having numerous dreams about a girl that he'd always thought that he hated, but it turned out it was quite the opposite. He dedicated a whole cave in his lair for all things Buffy. He often stole pictures and spied on her from the outside of the Summers' home. When Spike did finally say that he loved Buffy, she was disgusted and de-invited him from her home, but Spike's feelings did not deteriorate. His caring nature sometimes spread to caring about Dawn, Buffy's little sister. His obsession with Buffy grew to such a level that he made Warren build him a BuffyBot. Spike used this as his Buffy substitute. But things took a turn for the worse and Buffy found out about the BuffyBot. Spike was taken by Glory, but didn't spill about the Key and that it was Dawn. Buffy was touched by this, and pretending to be the BuffyBot, kissed Spike. A shocked Spike was...shocked. They maintained a kind of friendship, but when Buffy died Spike was crushed and blamed himself.