The Forsaken (2001)

Sean is on a cross-country road trip to attend his sister's wedding, when he does the one thing he was warned not to do; He picks up a hitchhiker. Soon, this trip is transformed into a nightmare. Sean's new companion, Nick, is infected with a deadly "virus" but is able to keep from turning because of a pill he takes. Sean and Nick pick up a dazed and frightened girl, Megan, who has been left for dead by the vampires. Unfortunately, Megan is not only a victim, but also human bait. Soon, Sean is infected and finally forces Nick to tell him everything he knows about the legend of the forsaken. Nick informs Sean that the only cure for their 'disease' is to kill the vicious leader of the vampire gang. What started as a casual cross-country trip, has now become a deadly race against time.