Against the Ropes (2003) .... Jackie Kallen 
In the Cut (2003) .... Franny Thorstin 
Searching for Debra Winger (2002) .... Herself 
Kate & Leopold (2001) .... Kate McKay 
How Harry Met Sally... (2000) (V) .... Herself 
Making of 'Hanging Up', The (2000) (TV) .... Herself 
Proof of Life (2000) .... Alice Bowman 
Hanging Up (2000) .... Eve 
You've Got Mail (1998) .... Kathleen Kelly 
Hurlyburly (1998) .... Bonnie 
City of Angels (1998) .... Maggie Rice 
Anastasia (1997) (voice) .... Anastasia 
Addicted to Love (1997) .... Maggie 
Courage Under Fire (1996) .... Captain Karen Emma Walden 
Restoration (1995) .... Katharine 
French Kiss (1995) .... Kate  
Century of Cinema, A (1994) .... Herself 
I.Q. (1994) .... Catherine Boyd 
When a Man Loves a Woman (1994) .... Alice Green 
Flesh and Bone (1993) .... Kay Davies 
Sleepless in Seattle (1993) .... Annie Reed 
Prelude to a Kiss (1992) .... Rita Boyle 
Doors, The (1991) .... Pamela Courson 
"Captain Planet and the Planeteers" (1990) TV Series (voice) .... Dr. Blight (1990-1991)
Joe Versus the Volcano (1990) .... DeDe/Angelica/Patricia 
When Harry Met Sally... (1989) .... Sally Albright 
Presidio, The (1988) .... Donna Caldwell 
Promised Land (1988) .... Bev 
... aka Young Hearts (1988) 
D.O.A. (1988) .... Sydney Fuller 
Innerspace (1987) .... Lydia Maxwell 
Armed and Dangerous (1986) .... Maggie Cavanaugh 
Top Gun (1986) .... Carole Bradshaw 
"Wildside" (1985) TV Series .... Cally Oaks 
Amityville 3-D (1983) .... Lisa 
... aka Amityville III: The Demon (1983)
"One of the Boys" (1982) TV Series .... Jane 
"As the World Turns" (1956) TV Series .... Betsy Stewart #6 (1982-1984) 
Amy and the Angel (1981) (TV) .... Denise 
Rich and Famous (1981) .... Debby at 18 years 

 TV guest appearances 
"Revealed with Jules Asner" (2001) playing "Herself" 
"Oprah Winfrey Show, The" (1986) playing "Herself" in episode: "Meg Ryan, Diane Keaton and Lisa Kudrow" 2/13/2000 
"Inside the Actors Studio" (1994) 
"Charles in Charge" (1984) playing "Megan Harper" in episode: "Hurricane Megan" (episode # 1.18) 2/13/1985 
"Charles in Charge" (1984) playing "Megan Harper" in episode: "War" (episode # 1.4) 10/24/1984