Nicotinamide adenine dinucleotide ( NAD ) serves as an electron acceptor in the metabolic pathway known as glycolysis . When NAD accepts its electrons it also acquires a proton (H + ) and is converted into NADH. NADH is a reduced electron carrier.
NADH then becomes oxidized in the first step of electron transport by mitochondrial complex I or NADH dehydrogenase. NADH contains flavin mononucleotide (FMN) as a bound prosthetic group , which is responsible for catalyzing the reaction.
NADH + H+ + FMN ------> NAD+ FMNH2
It is during this oxidation that ATP is produced, by the enzymes of the respiratory chain (See Fig. 7), which is imbedded in the inner membrane of the mitochondria.
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