(Sandman II #10 (fb, BTS) Despair and her sister Desire began a long series of intrigues to bring down their brother Dream

(Sandman II #41) - <1665> London, Despair observed the despair brought about by the plague. She was visited by Destruction, and he hinted that he was planning on splitting away from the rest of the Endless.

(Sandman II #47 (fb)) - <1695> Destruction called a family meeting of the Endless, and announced to Despair and the rest of his family that he was abandoning his duties as one of the Endless and taking his leave of them for good. Despair begged him to reconsider, but he’d already made up his mind.

(Sandman II #31) - <September, 1859> Despair presented Joshua Norton to Dream. Despair had driven him towards ruin and suicide, and speaking for herself, Delirium and Despair, she challenged Dream to save him through dreams. Dream found that Norton craved success and respect, so he gave him the dream of being Emperor of the United States.

(Sandman II #31) - <January, 1880> Norton I died, and Dream won his challenge against Despair. He never entered her realm once between the time Dream gave him his dream of being emperor and the time he died. Dream told Despair she should thank him for the lesson he taught her, but she didn’t see any lesson to be learned.

(Sandman II #10) - Desire called Despair to the Threshold and informed her of a new opportunity for their scheming to bring down Dream. A new dream vortex had been born, and was of Desire’s blood. If Dream destroyed the vortex he would bring ruin on himself, and if he didn’t the vortex would destroy the Dreaming.

(Sandman II #21) - Destiny called a gathering of the Endless, telling them a meeting with the Fates made him aware that he had to call the family gathering to set in motion a chain of events that would cause change and upheaval. Despair was reminded of her beloved brother Destruction, because at the last meeting Destruction abdicated his responsibilities as one of the Endless. Desire goaded Dream into going to Hell, and Despair pointed out that the Endless never argued like this when Destruction was still around.

(Sandman II #41) - Delirium visited Despair and asked her to help in a quest to locate their missing brother Destruction. Despite the fact that she longed to see her brother again, Despair refused to help, claiming to respect Destruction’s privacy, but really fearing what Desire would do if she helped Del.

(Sandman II #49) - Despair visited Dream and Delirium and told them she regretted not having gone with them to find Destruction, who had quit the Earthly plane after they found him. Despair reported to Delirium that Dream had doomed himself by seeking Destruction, because in order to find him he gave his son Orpheus the release of death, making him the rightful prey of the Kindly Ones. Despair and Desire always sought to undo Dream, but they were more scared than happy that Dream had done it to himself.

(Sandman II #56) - Despair was distraught when Desire cut off communication with the rest of the Endless.

Comments: Created by Neil Gaiman, Mike Drigenberg & Malcolm Jones III