(Batman I #326, 327) - Professor Milo survived his encounter with Anthony Lupus, but was left badly scarred. Milo, acting as director of Arkham Asylum, released inmates to commit crimes. Batman went on patrol, spotting a man on a motorcycle robbing the jewelry exchange. He threw a batarang at his head, which bounced harmlessly off his bike helmet, and the man tried to run Batman down. Batman jammed a metal rod in his front wheel, causing him to crash. He was injured, but took off his helmet, smashed Batman in the head with it and ran off. Batman recognized him as Mad Dog Markham, an Arkham Asylum resident, and checked in with Gordon. Gordon told him about a recent investigation of a murder bearing the earmarks of Arkham inmate Kid Gloves McConnell, and decided to ring up Arkham. The director assured Gordon both men were safely in their cells, but Gordon knew something wasn’t right. Batman decided to go undercover, posing as Shank Taylor, a criminal suffering from paranoid delusions. Milo brought him to his office, sedated him, and assured him he’d be friends. Batman escaped his straightjacket, escaped his cell and went around Arkham to investigate, finding Markheim in his cell with a sling around his arm. He knew there was something afoot, but returned to his cell before his absence was noticed. Professor Milo had cameras on all the cells and witnessed his ability to escape at will, so he had orderlies bring “Shank” to his office. Milo’s megalomania kicked in, and he wanted to explain his whole plan to shank. He’s replaced the actual director, having him locked in one of Arkham’s padded cells, and had his underlings act as orderlies. He released inmates to commit crimes in exchange for 50% of their take in exchange for an ironclad alibi for them. He offered Shank a cup of tea, saying he knew he was a veteran jewel thief and could use a man like him. Shank pretended to drink, fearing the tea was drugged, and turned down Milo’s offer. Milo said he didn’t really have a choice in the matter and had his orderlies drag Shank back to his cell. Batman escaped his cell again, and found a Batman costume in joker’s cell that he was using for target practice. He slipped it on, but suddenly felt faint and collapsed. He awoke in a straightjacket surrounded by inmates who thought they were famous historical figures such as Napoleon and Joan of Arc. Milo told him he was delusional for thinking he was Batman and would prove it. Milo knew it would have been safer to simply kill Batman, but wanted to break his mind and leave him as a permanent inmate of Arkham. He dared Batman to show his skills and escape his straightjacket, but batman found he couldn’t. Batman wasn’t falling for Milo’s mind games, realizing he’d been drugged. Milo admitted he’s coated his teacup with neurotoxin, and left his orderlies to kill batman. Batman easily fended them off and convinced “Joan of Arc” to take one of the orderlies’ knives and free him. Batman went to Milo’s office, where he was wearing protective clothing and a helmet. He had a vial of the toxin he'd used on Batman earlier and smashed it, saying a full dose would drive Batman insane forever. Batman used his cloak to keep from bretahing it in, but the inmates had followed him, and seeing Batman as a leader, attacked Milo. They ripped off his protective mask, and milo got a full dose of the toxin, driving him mad.

(Batman: Joker’s Apprentice #1) - Joker chose fellow inmate Arthur Rankle, a serial killer who raped and killed eighteen women before Batman took him down, as his apprentice. After teaching him everything he knew he orchestrated his escape. He told Joker he’d need two men to help him carry out his big kill, and Joker had Professor Milo connect him with Dr. Thomas DeGeorge, a doctor who was locked up after it was discovered he was causing seizures in his patients so he could save them and seem a hero, and Calvin Marshall, a brute full of rage who killed a nun in broad daylight for rejecting his advances. He had DeGeorge knock on a woman’s door, in tears that his dog was lost, and when she let him in Calvin came close behind and brutally slaughtered her. Rankel filmed the incident, and mailed it to the police under the alias DeMille. The authorities, believing Calvin to be DeMille, saw how sloppy his methodology was, and were convinced he would easily be caught after making a mistake. Weeks later Rankel and his crew had killed 23 more women and Commissioner Gordon was frustrated that he didn’t have a single lead. He met with Batman and said he suspected they weren’t dealing with a simple madman, they were dealing with a lunatic with a purpose, and Gordon suspected he was after Batman. Batman contacted Oracle, and after hours of research she came up blank, but planted the idea that Batman was looking for more than one unsub. Batman confirmed the hypothesis when he realized the fingerprints left behind at the crime scenes were identical except for their size, and knew the unsubs were using false fingerprints. Batman confronted Professor Milo, who spilled his guts, but then called joker, who’d foreseen what would happen, and Joker told Rankel to get ready to ambush Batman. Rankel locked the film studio once Batman was inside and Calvin and Thomas chased him through old film sets with guns and a flamethrower. Batman defeated Calvin and Thomas, and when confronted Rankel begged Batman not to hurt him and gave up.