In Sensational Spider-Man #35, a string of Spider-Man impostors – imbued with powers and costumes nearly identical to Spider-Man – have descended upon Manhattan. Spider-Man rescues one of the imprisoned doppelgangers from prison – and near death – but not before disgusting, spider-like appendages uncontrollably grow out of the spider-replica's abdomen. A second Spider-dupe has turned into an arachnid mutation, spouting spider eyes and fangs. Left unchecked, the boy's metamorphoses will kill them. This forces Spidey to enlist his most brilliant scientific colleagues - Dr. Curt Connors, a.k.a. the Lizard, and Dr. Reed Richards of the Fantastic Four - Spidey sets out to find the cause of these transformations and cure them. Unbeknownst to the wall-crawler, the demented Dr. Calvin Zabo – inventor of a serum that transforms him into the hulking brute, Mr. Hyde – is the one responsible for the cruel experiments. And his latest abducted test subject is Jordan Harrison...Mr. Parker’s best high-school biology student.

In Sensational Spider-Man #36, Spider-Man sneaks into Dr. Calvin Zabo's hidden lair, just as the mad scientist is getting his experiment started on Jordan Harrison. But, the wall-crawler is spotted by Zabo’s surveillance cameras.

ACT 1: The story opens to a flashback of when Dr. Calvin Zabo developed the serum that transforms him into the hulking brute that is Mr. Hyde. Reference to a book by Robert Louis Stevenson is made, while in present time, Zabo transforms into Mr. Hyde and goes out in search of Spider-Man, whom he spotted with his surveillance cameras.

ACT 2: Having searched the sewer tunnels for hours, Spider-Man finally locates Zabo's hideout, which consists of dozens of cells stacked on top of each other, from left to right, arranged like a honeycomb. As Spidey further investigates, he comes across Jordan Harrison, imprisoned in one of the cells. Spidey does not understand why Jordan was kidnapped since he does not fit the profile (the other young men who were abducted were all homeless). When asked by Spidey how he got there, Jordan answers that his kidnapper told him he killed his mother and that he was going to kill his girlfriend, Madeline, right there and then, if he did not come with him. Having heard enough, Spidey tries to break the Plexiglas window that acts as the cell door, but to no avail. Nursing his sore shoulder – from attempting to break the glass with it – Spidey asks Jordan who is doing this to him. Jordan reveals that his kidnapper was none other than Dr. Calvin Zabo. On cue, Spidey's spider-sense kicks in, warning him of danger. Mr. Hyde has arrived.

ACT 3: Felicia Hardy (a.k.a. the Black Cat) brings in another Spider-Man doppelganger to Detective Fogg at the police precinct. This one is dressed in the Scarlet Spider costume. Felicia indicates that she is used to swing around with older and more experienced guys, implying that she has a good relationship with the real Spider-Man (who is a criminal outlaw at this point). Fogg comments that Spider-Man must appreciate what she is doing for him and gives her the "I know you know where Peter Parker a.k.a. Spider-Man is hiding" look. Felicia tells Detective Fogg that she is no intention of telling him where Spidey is, prompting Fogg to tell her that if she knows where he is, she should relay a message to him, which is that there is at least one more doppelganger out there missing. With that said, he brings Felicia into an interrogation room and he introduces her to Jordan Harrison's mother and girlfriend Madeline (horribly drawn by Bachs – she looks like a prostitute), who witnessed Jordan being abducted. Jordan's mother explains that Zabo threatened Jordan by telling him he had already killed her and that he was going to kill Madeline if he did not get into his limousine. When Felicia asks how she knows about the abduction, Jordan's mother explains that it was Madeline that related it to her. Madeline goes on to say that he tried to take her too; however she escaped. Jordan's mother begs Felicia to locate Spider-Man so that she can ask him to find Jordan and that when he does (if he does indeed), to tell Jordan that she is not dead and that Zabo fabricated the whole story.

ACT 4: Back in the sewer systems, Mr. Hyde tries to tackle Spidey but Spidey dodges the attack. Hyde slams into Jordan's Plexiglas cell door, causing a small fracture to appear in the glass. Spidey tries to convince Hyde to calm down and revert back to his former self but his attempt to reason with the brute is futile. In the ensuing battle, Spidey is able to momentarily blind Hyde by causing a steam pipe behind him to burst and spray its high pressure content into his face. In his cell, Jordan Harrison uses a pipe to apply pressure on the Plexiglas cell door, where Hyde cracked it. After pushing on it for a few seconds, the cell door shatters into a hundred pieces. Jordan is free; a look of determination on his face.

ACT 5: As a half-blinded Mr. Hyde tries to locate Spider-Man – who is clinging to the tunnel ceiling above him – he reveals that his alter ego, Dr. Zabo, was trying to dissect Spidey's psyche to find out what drives him to do what he does and to see what makes him tick. Rather unimpressed that Hyde experimented on children, Spidey attacks him from above and proceeds to web his eyes shut with webbing. Pulling on the webbing with all his strength, Hyde reveals that he embraces his darker impulses because he wants to peel back the layers of humanity and see what animal heart beats underneath. Having said that, he pulls the webbing off his eyes, ripping his eyelids in the process (Needless to say that Spidey is shocked). Elsewhere, Jordan Harrison has made it into Zabo's laboratory. Blood trickling down his face, Hyde tells Spider-Man to take a good look at his black costume and ask himself whether he embraced his darker self or not. Spidey is speechless. In Zabo's laboratory, Jordan locates several dangerous chemicals.

ACT 6: Hyde slams Spidey into a brick wall and holds him up there. Spidey manages to break free from the hulking brute, just as Jordan shows up, holding a vial of chemicals and telling Spidey that Hyde killed his mother, did something to him, and therefore must die. Spidey appeals to Jordan to put down the chemicals, because they cannot be sure that Zabo did kill his mother. Jordan replies that, after all that Zabo has done, he should not live. Hyde taunts Jordan to throw the chemicals at him, prompting Jordan to call him a murderer and tell him to shut up. Recognizing the darkness Jordan is felling – the same darkness that Peter is feeling at the moment – Spidey shoots a web toward Jordan because, even though Hyde may deserve to die, it should not be by Jordan's hand.

ACT 7: Later, on a rooftop somewhere, Peter Parker tells Felicia Hardy that the vial of chemicals Jordan was holding contained acid and that, although he tagged it with his webbing, enough acid got on Hyde's face to blind him and almost completely burn his face off. Strong as Hyde is, he was fairly helpless after that. Spidey then proceeded to beat him into unconsciousness. Felicia comments that "all's well that ends well", but Peter disagrees. He explains that Zabo created the doppelganger to prove that given the proper circumstances – a family member's traumatic death for instance – someone like him would be driven to embrace the dark side. Jordan did just that. He would have killed Mr. Hyde if he could have. Peter saw it in his eyes. Felicia remarks that he (Peter) prevented that from happening, even with everything going on in his life. Peter replies that the damage had already been done and that Jordan knows how close he came to taking a life and now he has to live with that part of himself for the rest of his life. The story concludes with an excerpt from the book "Dr. Jekyll and Mr. Hyde" by Robert Louis Stevenson (whom was referred to earlier).

The end…for now.