INSTITUTE OF SCIENCE
www.instituteofscience.com
RE: Book proposal Infectious Etiologies of Neuropsychiatric Disorders
Thursday, June 13, 2002 12:21 AM
From: "S H Fatemi" <S-Houssein,Fatemi-1@tc.umn.edu>
To: "S.H. Shakman" <shshakman@YAHOO.COM>
06-12-2002
Dear Dr.Shakman:
Thank you very much for your kind remarks on my book proposal.Indeed ,if this
proposal is accepted,I would appreciate if you could agree to contribute a
chapter to it.
Sincerely,
S.H.Fatemi,M.D.,Ph.D
[Chapter as drafted for
(subsequently-cancelled) Wiley book:
Shakman-History-Rosenow.pdf]
----Original Message-----
From: S.H. Shakman [mailto:shshakman@yahoo.com]
Sent: Monday, June 10, 2002 11:29 PM
To: CBrabant@wiley.co.uk
Cc: Fatem002@umn.edu;
torreyf@stanleyresearch.org
Subject: Re: Book proposal Infectious Etiologies of Neuropsychiatric Disorders
Dear Charlotte Brabant
Thank you for contacting me regarding Dr. Fatemi's book proposal, "Infectious
Etiologies of Neuropsychiatric Disorders".
Thanks also to Dr. Fatemi for the courtesy of soliciting my opinion. My relevant
perspective builds on experience as a (former) health program analyst for the
U.S. State Dept. (AID) and science researcher (
www.InstituteOfScience.com/Nature338‑456.html),
and specifically is based primarily on subsequent intensive analysis of the
microbiological works of the late E.C. Rosenow, M.D. (1875-1966). As the Mayo
Foundation's longtime head of experimental bacteriology (1915-44), Rosenow
compiled compelling direct evidence of an infectious etiology (substantially
satisfying and additional to Henle-Koch criteria, e.g., see
www.InstituteOfScience.com/AUTOMED/40R3.HTM) for a range of systemic conditions,
including diseases of the nervous system. His work included reference to a
number of conditions mentioned in Dr. Fatemi's proposal, i.e., encephalitis,
herpes, influenza, meningitis, mental deficiency, schizophrenia, syphilis and
Tourettes. Rosenow concentrated on epilepsy, schizophrenia and closely related
disorders for over a decade following his retirement from Mayo, building on
decades of experience with other nervous system diseases, as summarized in my
2001 Stanley Symposium abstract and associated presentations: (www.Instituteofscience.com/StanleyAbstract.html),
(www.angelfire.com/ca/instituteofscience/StanleyPoster.ppt
& (www.angelfire.com/ca/instituteofscience/StanleyLecture.ppt)
Notwithstanding its currently obscure status, Rosenow's microbiological work
is monumental, consistent and seemingly impregnable, and thus arguably
conclusively-supportive of a modern consensus that infection is involved in the
cause of schizophrenia. As such, it is somewhat amazing and a tribute to the
instincts of its advocates of the modern view that it has been able to evolve so
far in this direction wholly independently of Rosenow's documentation of
microbiologic specificity. At the same time, while the modern view does not
build on Rosenow, neither does it contradict nor supercede him.
Regarding your questions:
1. Is there, in your opinion, a need for a publication of this type?
Yes. The above-described historical-bacteriological view provides substantial
independent support for such a publication, at a minimum, as well as for the
overall concept of involvement of infection in the cause of schizophrenia and
closely related disorders. However, even without such support, publication of a
book featuring the modern view would still be appropriate.
The modern view on the role of infection in schizophrenia and related
neuropsychiatric conditions, as incorporated within Dr. Fatemi's proposal,
indisputably represents a fundamental shift in thinking that has occurred within
recent years, encompassing psychiatry and psychology. This shift has been
characterized by U.S. Surgeon-General David Satcher as a "revolution in science"
( www.surgeongeneral.gov/library/mentalhealth); and is prominently reflected in
the U.S. NIMH position on the cause of schizophrenia: "scientific theories
suggest there is a genetic component, possibly combined with an exposure to
infections either in the womb or during early childhood" (www.nimh.nih.gov/publicat/schizoph.cfm#schiz2).
From a historiographic perspective alone, considering the dominance of the
Freudian-influenced view over much of the 20th Century, this is a big story that
certainly merits book-length treatment.
In a sense Rosenow anticipated the modern view with his reference to causality
by infection in combination with inherited or inherent conditions (which he
concluded may themselves contribute to specifity, not merely vulnerability;
e.g., see www.InstituteOfScience.com/AUTOMED/55R1.HTM), except that his
emphasis was on later infections rather than prenatal or other early ones
(although he did document possible prenatal passage as discussed below in para.
3).
2. Do you think that the proposed book would fulfill such a need, if indeed one
exists?
Yes. Dr. Fatemi's roster of contributors seemingly guarantees that the
predominant works associated with the modern view of schizophrenia, as relates
to infectious hypotheses, will be comprehensively represented.
3. Please comment on the (a) content of the book and its scope. Are there any
obvious (b) gaps and/or areas that you would wish to see covered in greater
detail? Have you any (c) other editorial suggestions which you feel might
improve the usefulness and value of the proposed book?
Two fundamental areas addressed in Dr. Fatemi's proposal might be further
amplified, with corresponding revisions reflected as appropriate elsewhere in
the proposal: (1) separation of consideration of incontestably-developmental
disorders from others, as indicated by separate treatment of autism in Dr.
Fatemi's outline; and (2) explicit consideration of types of infections other
than pregnancy- or birth-related infections, e.g., items in Dr. Fatemi's
definition of topic and proposed outline.
(1) Separation of Incontestably-Developmental Disorders from Hypotheses
Dr. Fatemi's separation of consideration of autism within a separate chapter
seems appropriate and might be made even more distinct, although it is
acknowledged that NIMH and others tend to group autism within listings of
neurological disorders including schizophrenia, the term "autism" was originally
used by Bleuler, 1908, as a characteristic of schizophrenia (
www.priory.com/schizo.htm),
and Dr. Fatemi's own work relates to both autism and schizophrenia. Fundamental
issues concerning autism and other conditions that are indisputably
developmental (with or without neuropsychiatric manifestations) are different
from those concerning disorders for which developmental origins are not
established. In the case of autism, the question seems to be not whether a
developmental insult occurred, but rather what was its nature. In the case of
disorders that are hypothesized but not yet established to be developmental, the
task of determining the validity of any sort of developmental origin is itself
fundamental.
Although there is logic for coordinating assessments of possible effects of
developmental infections on both categories, and this information may even
become decisive in determining the extent to which a given disorder in the
undecided category may be developmental, careful and separate consideration may
help avoid possible confusion by association.
In this same vein, it would seem prudent to similarly separate out other special
cases from consideration of the issue as to whether, and to what extent,
"typical" adult-onset schizophrenia may have developmental roots. From this
perspective, the finding that some schizophrenics have minor physical anomalies
or other congenital abnormalities seems less an argument that schizophrenia is
developmental and more an argument that those with the likes of congenital
abnormalities be excluded from examination of this issue (i.e., developmental or
not) as relates to the cause of adult schizophrenia. Such separate consideration
would also be seemingly indicated in the case of not only multi-dimensionally
impaired children but also childhood schizophrenia in general, so as to assure
maximally-objective assessments of causation for each involved category.
From this standpoint, an alternate organizational approach based on type of
condition may be preferable; however, regardless of final organizational scheme,
specific provision might be made in the outline for overview discussions of
cross-cutting topics or analyses, e.g. the nature of Dr. Fatemi's own research.
(2) Consideration of Types of Infections Not or Not-Necessarily Related to
Pregnancy or Birth
While issues related to prenatal, etc. insults are of paramount importance in
considering decidedly-developmental conditions, some broader or other means of
categorization seems appropriate in the case of schizophrenia etc. Estimates of
how much schizophrenia may be developmental in origin range from "half or more"
( www.schizophrenia.com/news/causes2.html) to "only a minority" (
www.priory.com/psych/aetioschiz.htm)
or one subgroup ( www.priory.com/psych/neurodev.htm). Either position allows that
at least some schizophrenia is not developmental, seemingly calling for some
degree of explicit attention to the issue and specifics of the possible relation
of schizophrenia and other neuropsychiatric disorders to infections that are
independent of developmentally-related events.
Accordingly the concept of non-developmental adult-onset schizophrenia, as well
as the likes of adult-onset conditions listed by Dr. Fatemi in definition of
topic and proposed contents, e.g. Parkinson's and psychosis after adult onset
influenza, might be placed in an "other" or "adult" category so as to allow for
consideration distinct from (typically-immediate) post-natal events.
Such an "other" category is also supported by other circumstantial evidence of
infectious involvement without reference to birth-related events. For example,
according to Dr. Fatemi's proposed co-author Dr. Torrey, "There is some evidence
that individuals with schizophrenia have more infections, heart disease, type II
(adult onset) diabetes, and female breast cancer" (per
www.psychlaws.org/GeneralResources/Fact5.htm).
Such a circumstance may be taken to suggest a direct relation between infectious
agents in schizophrenia and these other conditions, as also may be indicated in
the above-mentioned association of psychosis and influenza, etc. In addition,
similar geographic patterns of schizophrenia and MS, and similar results of twin
studies for schizophrenia, MS and polio, as discussed by Drs. Torrey and Yolken
(www.stanleylab.org/Document/PDFDoc/Viruses,schizo%20bipolar.pdf), are at least
suggestive of involvement of similar infectious processes (e.g. as directly
addressed by Rosenow and associates).
Additionally, the direct nature of adult onset neuropsychiatric symptoms
associated with several infectious diseases as per Dr. Fatemi's definition of
topic, in contrast to the indirect nature of hypotheses involving early insults
and later symptoms, conceptually argues for: consideration of possible more
general applicability of the former (more direct) mechanism; and specific
discussion of justification for exploring special infectious mechanisms to
explain neuropsychiatric disorders, as distinct from general infectious
mechanisms under consideration in other areas of medicine.
Further, it is noted that the modern view understandably embodies component
hypotheses that may themselves be in conflict. D.R. Weinberger, a key advocate
of the neurodevelopmental model for schizophrenia (
www.acnp.org/G4/GN401000112/CH110.html),
has noted "a surprisingly large number of investigations over the past three
decades" into obstetrical complications as possibly contributing to
schizophrenia, and has suggested that validation of a prenatal connection could
make obstetric complications "irrelevant". He also indicated that this could
make explanation of delayed onset problematic, due to the "unlikely scenario of
a secondary primary pathology". (This reasoning might also place the modern view
in conflict with Rosenow's distinctly later-onset ostensively-primary
pathology.) In any case, the challenge of explaining the presumed latency
period, between proposed early insult and late onset of schizophrenia, etc.,
seems also deserving of special attention and specific mention in the final book
outline.
Moreover, as per Weinberger and elsewhere, Torrey has expressed doubts about a
relation between schizophrenia and: mother's influenza during pregnancy (
www.webmd.lycos.com/content/article/1728.52613),
and early childhood viral nervous system infections (http://ww.surgeongeneral.gov/library/mentalhealth/chapter4/sec4_1.html).
These widely acknowledged controversial circumstances seem to call for special
efforts to comprehensively incorporate critical assessments of the modern
perspective, as well as its component hypotheses, so as to avoid any possibility
of being perceived as a partisan endeavor.
It may be noted incidentally that Rosenow seems to have documented prenatal
passage of infection as conclusively as possible, in the case of epilepsy, as
this involved an infectious agent injected into a pregnant rat and seemingly
passed to one of four offspring, which agent was then recovered from the
affected offspring and passed to other animals (
http://www.instituteofscience.com/AUTOMED/52R2.HTM).
Hippocrates also briefly mentioned possible ill-effects of in-utero infection,
this as related to season of birth, within paragraph 12 of Aphorisms Section
III. This involved scheduled delivery in a dry Spring following a mild Winter,
which was associated with possible spontaneous abortion or immediately-evident
feeble offspring. However, his overwhelming emphasis (i.e., 22 other paragraphs)
involved more direct considerations of seasonality of onset of disease, e.g.,
associations between rainy seasons and arthritis, Winter and pneumonia, Spring
and maniacal, etc.
Rosenow also addressed seasonality of onset with reference to infection, e.g.,
involving infective agents isolated in studies of schizophrenia (www.Instituteofscience.com/AUTOMED/55R2.HTM),
violent criminality (www.Instituteofscience.com/AUTOMED/51R5.HTM), stomach
ulcers ( ww.Instituteofscience.com/AUTOMED/16R8.HTM, and effects of solar
radiation on seasonal change in specificity (www.Instituteofscience.com/AUTOMED/50R3.HTM).
The modern perspective on seasonality has primarily focused on studies of season
of birth, with reference to the above-cited Hippocratic observation and the
possibility that infectious agents may contribute to reported winter-spring
excess of births for schizophrenia and other conditions (
www.stanleylab.org/Document/schizohr.html).
Modern researchers also deal with seasonality of onset with reference to
seasonal affective disorder (SAD), a condition that is helped by light therapy.
However, in that geographic incidence of SAD is similar to MS and schizophrenia,
and light therapy also has been found to help with some non-seasonal disorders (
www.mhsource.com/pt/p940216.html),
possible involvement of an infectious component for SAD might merit
consideration.
Rosenow's methodology might be of service in shedding some light on this and
other questions concerning the possibility of specific infection related to
schizophrenia. For example, he found close correlations between schizophrenia
and some psychoneurotic and psychophysiologic disorders in terms of
agglutinative titer of blood serum, in sharp contrast to negative results for
well controls and chronic brain syndromes due to syphilis. He also found
surprisingly strong indications of specificity (for an infectious agent isolated
from schizophrenia) in cases of "mental deficiency" (
www.InstituteOfScience.com/AUTOMED/55R2.HTM),
implying that such a condition might be amenable to correction through specific
vaccination, etc.
Of course, the bottom line on any sort of correlations is that they do not in
and of themselves cause diseases or prove causation. As emphasized by Dr. Torrey
at the conclusion of his recent book, The Invisible Plague, p. 333: "The
challenge, therefore, is not only to identify correlations but also to prove
that they have some causal connection to insanity." In this regard, the
continuing relevance of Koch's classic standards for proving causation by
infection has been prominently emphasized by Dr. Yolken (per Carl Zimmer,
Science 293, p. 1977, 14 Sept. 2001). The Rosenow perspective is wholly in
accord with Drs. Torrey and Yolken on this point, emphatically asserting that
and demonstrating how these criteria can indeed be fulfilled, even for chronic
diseases like schizophrenia.
4. Please comment on the author's standing in and contributions to the field.
Are you familiar with the author? Do you think this author is well-suited to
writing the book as proposed?
Dr. Fatemi seems well positioned to serve as principal editor based on his
familiarity with the contemporary neuropsychiatric research perspective and
community, openness to the historical perspective, and the distinctly
independent quality of his own work.
5. What do you consider to be the primary markets for this book? In your
opinion, is this book primarily a reference, text or monograph? NA
6. Are there any undergraduate and/or postgraduate courses ¼ NA
7. Do you know of any existing publications on this subject or manuscripts in
preparation which are likely to compete with the book under review? Please
supply details and compare principle features.
Some works with which I am associated also deal with the subject of the relation
between infection and neuropsychiatric disease. They are not competitive in that
they do not refer to the modern position; however, they do deal with the same
end. Information copies of some of these materials have been sent to Dr. Torrey
over the past year, in an effort to make their existence known to modern
researchers. Under separate cover I will be sending a copy of them to you, and
would welcome discussion of any interest you may have in making them available
on a broader scale.
8. Could you suggest possible additional referees? (Please provide full
addresses and/or telephone numbers where possible) NA
9. Are there any additional comments you wish to make concerning the proposed
book? NA
10. In the event of any discussion of your comments with the author(s) and/or
editor(s), do you have any objection to the disclosure of your identity, or
would you prefer to retain reviewer's anonymity?
Please feel free to discuss these comments with Dr. Fatemi; in any case I am
sending him a copy, insofar as my above-cited 2001 Stanley Symposium
presentation materials, as submitted but not yet posted on Dr. Torrey's
website, has not otherwise been available to him. (He has seen the abstract
as printed in a book distributed at the symposium.) I sincerely hope this
information will serve him constructively.
A courtesy copy is also being sent to Dr. Torrey, in that his work is
prominently cited herein, and also in appreciation for the vehicle of his 2001
Stanley Symposium which indirectly enabled this contact.
With kind regards,
S. H. Shakman, Ph.D.
Institute Of Science
www.InstituteOfScience.com
cc. Dr. Fatemi, Dr. Torrey
****************************************************************
Initial email request from Wiley (London) for review Fatemi book proposal;
inluding:
-- Fatemi book proposal
-- review questionnaire
--------------------------------------------------------------------------------------
To: shakman@instituteofscience.com
From: CBrabant@wiley.co.uk
Date: Thu, 28 Mar 2002 14:37:32 +0000
Subject: Book proposal Infectious Etiologies of Neuropsychiatric Disorders
Dear Dr. Shakman,
Please allow me to introduce myself as Senior Publishing Editor in the Life &
Medical Sciences at John Wiley & Sons. I am responsible for our publishing
programme in psychiatry and neuroscience and wondered if I might presume to ask
a favour. I am currently considering a proposal for a new book titled Infectious
Etiologies of Neuropsychiatric Disorders to be edited by S. Hossein Fatemi.
Given your expertise, I would be most grateful if you could take a few moments
from your busy schedule to review the attached proposal from the author
outlining the contents and scope of his book. I have also attached a reviewer
questionnaire to help you frame your comments. In exchange for your efforts, I
am able to offer you a modest honorarium in the form of Wiley Books up to the
value of £75/$100.
I am keenly interested in your opinion on whether this book would be a valuable
addition to the literature and, if so, what it would ideally contain. What do
you think of its proposed scope and coverage? To whom do you think it will most
appeal? Do you think it correctly identifies its target market? Are you familiar
with the editor? I would also be interested in your views on how this book
compares with competing volumes.
If you have any questions, I would be happy to provide additional information;
please don't hesitate to contact me.
Thank you in advance for your assistance; I look forward to receiving your
comments shortly.
Until then, best wishes
Yours sincerely
Charlotte Brabants
Senior Publishing Editor
Life & Medical Sciences
Tel: +44 (0) 20 8326 3842
(See attached file: fatemi propsosal.doc)
(See attached file: Fatemi REVQUES.doc)
--------------------------------------------------------------------------------
NEW BOOK PROPOSAL
AUTHOR AND TITLE INFORMATION
Tentative book title and subtitle (if any): Infectious etiologies of
neuropsychiatric disorders
1. Author's/Editor's full name: S. Hossein Fatemi, M.D., Ph.D.
2. Position and Affiliation: Associate Professor of Psychiatry, Cell Biology &
Neuroanatomy, Adjunct Associate Professor of Neuroscience
3. Full Mailing addresses: Department of Psychiatry, Division of Neuroscience
Research, University of Minnesota Medical Center, MMC 392, 420 Delaware Street
SE, Minneapolis, MN 55455, USA
4. Telephone: 612-626-3633
5. Please list details of co-author(s) and their affiliations:
Co-editor, Dr. R. A. Machon
Professor of Psychology
Loyola Marymount University
Potential co-authors:
Dr. S. Mednick, University of Southern California
Dr. E. Fuller Torrey, Stanley Foundation
Dr. R. Yolken, Johns Hopkins University
Dr. M. Pletnikov, Johns Hopkins University
Dr. K. Lieb, University of Freiburg
Dr. S. Swedo, NIH
Dr. S. Brown, Columbia University
Drs. P. Wright & R. Murray, Institute of Psychiatry, London
Dr. R. Firouzi, University of Laennec, France
Dr. S. Kim, University of Minnesota
SUBJECT MATTER
6. Definition of topic
Recent immunologic, epidemiological, microbiologic and neuropsychiatric studies
point to infectious etiologies of several important neuropsychiatric disorders
e.g. schizophrenia, autism, obsessive-compulsive disorder, depression &
Tourettes disease. Additionally, several infectious diseases including human
influenza virus, HIV, syphilis, Lyme disease are associated with
neuropsychiatric symptoms following transmission of infectious agents to the
central nervous system of the adult individuals. Accumulation of experimental
evidence also points to potential for peri-, pre- and postnatal infections as
causes for several neurodevelopmental disorders such as schizophrenia, autism,
cerebral palsy and mental retardation.
7. Please write a short description of your book which could be modified for
promotion purposes.
This comprehensive and integrative book examines the role that infectious agents
play in the etiology of various neuropsychiatric disorders, including
schizophrenia, autism, mood disorders and obsessive-compulsive disorder. Recent
advances in technology and methodology now afford a meaningful examination of
the infectious etiologies of neuropsychiatric disorders. Drawing on the
contributions of an international panel of experts, this work provides an
unprecedented analysis of this emerging field by examining evidence from
epidemiologic, serologic and animal models.
8. Please outline your reasons for proposing a new book in this area:
A. near absence of a comparable book in the literature
B. availability and readiness of a group of selected experts in the field to
contribute to this book
C. availability of state of art data collected over recent years
D. presence of clinical data pointing to infectious etiologies for certain
neuropsychiatric disorders
E. presence of experimental data from animal models providing convincing
information on role of infectious agent causing brain disorders
9. Please list major features of your book which make it unique:
This book is the first serious attempt at enumerating experimental and clinical
data regarding the infectious etiologies of several important neuropsychiatric
disorders such as schizophrenia, autism, mood disorders and obsessive-compulsive
disorder. Features which make this book unique is the expertise of the authors
of this book; additionally, presented data are products of years of laboratory
and/or clinical studies which have been published in refereed journals.
10. Please list proposed contents, including section and sub-section headings
(possibly attach a separate document)
I. Introduction to infectious etiologies of neuropsychiatric disorders
II. Prenatal viral infections and schizophrenia
A. Epidemiologic data on influenza
B. Epidemiologic data on rubella
C. Serologic data on herpes
D. Serologic data on influenza
E. Animal models
i. mouse model of human influenza viral infection
§ structural and protein data
§ behavioral data
III. Prenatal infections and autism
A. Epidemiologic data
B. Serologic data on rubella
C. Animal models
i. influenza
ii. Borna disease
iii. Choriomenigitis
iv. CMV
III. Postnatal infections and psychiatric disorders
A. Epidemiologic data
B. Serologic data on OCD and streptococcus
C. Adult Borna disease and mood disorders
D. Von Economo's encephalitis, Parkinson's and psychosis after adult onset
influenza
IV. Conclusion
MANUSCRIPT INFORMATION
11. Approximately how many pages, would you expect your book to contain? 200-300
12. How long do you estimate it will take for delivery of the completed
manuscript? 8 months
13. Will you be able to prepare your manuscript on a word-processor? Yes
14. If so, what software will you be using? Microsoft Word 98
15. Please list any special physical features you would expect to include:
Tables, illustrations, photographs
THE MARKET
16. Please identify the readership for your book:
16.1 Primary Market: Psychiatrists, neuroscientists, scientists, neurologists,
infectious disease experts
16.2 Secondary Market: graduate and medical students
17. Please indicate any societies, professional organizations, companies or
other groups which might want to know about your book:
American Psychiatric Association (APA)
Society for Neuroscience
American Medical Association
Biological Psychiatry
American College of Neuropsychopharmacology
Cure Autism Now
National Alliance for Research in Schizophrenia and Depression
18. Please list any key journals in this area and any major conferences:
Journals Conferences
American Journal of Psychiatry Biological Psychiatry
General Archives of Psychiatry American College of
Biological Psychiatry Neuropsychopharmacology
Molecular Psychiatry APA
J Autism & Developmental Disorders Society for Neuroscience
Neurology International Meeting for
Neuroimmunology Autism Research
Neurovirology NIH (NIMH, NIDR, NINDR, NICII)
Proceedings of the National
Academy of Sciences
Lancet
New England Journal of Medicine
Schizophrenia Research
TEXTBOOKS
19. For what specific courses is your book written? The book is aimed primarily
at psychiatrists, neuroscientists, and neurologists and secondarily at graduate
students and medical students dealing with pathophysiology and neuropsychiatric
disorders.
19.1 Level: Scientists
19.2 Typical student numbers: 150-200 medical students/per class
19.3 Length of course: 1 semester
19.4 Is the course optional or compulsory? Optional
19.5 Would your book be for main adoption, supplementary reading or recommended
reading? Supplementary or recommended reading
19.6 Can you suggest any lecturers who would be particularly interested in
hearing about your textbook?
19.6.1 In Europe
19.6.2 Dr. R. Murray
Dr. P. Falkai
Dr. Bogerts
19.6.3 In North America
Dr. D. Pearce, Emory University
Dr. Srivastava, McGill University
Dr. D. Weinberger, NIH
Dr. B. Lipska, NIH
Dr. P. Patterson, Cal Tech
Dr. I. Lipkin, Cornell
19.6.3 Elsewhere
REVISIONS
20. By what percentage has this new edition of your book increased/shortened? NA
21. Has your approach to the subject changed considerably from the previous
edition? If so, how? NA
22. Please list up specific changes/differences between the old and new edition
of your book and how these changes will enhance this edition: NA
COMPETITION
23. Please list in order of importance, any existing books which are related toy
our book. Please supply 9ifpossible) author/editor, publisher, publication data,
price and any further information you feel relevant.
There are currently, no published books exclusively dealing with this topic in
the market; however, a book entitled "Prenatal Exposures in Schizophrenia"
edited by Susser ES et al (APA, 1999) has two chapters dealing with infectious
etiologies of schizophrenia.
24. Please outline in what ways your book is better than and differs from the
titles mentioned in previous section. NA
REVIEWS
25. Please give an international list of persons qualified to give an opinion on
your book proposal:
1. Dr. N. Muller, Ludwig-Maximillan University, Germany
2. Dr. J. Blomberg, Academic Hospital, Uppsala, Sweden
3. Dr. S. H. Shakman, Institute of Science, California
4. Dr. E. Marcotte, McGill University
5. Dr. P. Harrison
6. Dr. D. Pearce, Emory University
7. Dr. M. Hornig, Cornell University
8. Dr. N. Weatherall, Viromed Laboratories, Inc., Minneapolis
9. Dr. J. S. Oxford, St. Bartholomew's and the Royal London School of Medicine &
Dentistry
10. Dr. M. Ison, University of Virginia
11. Dr. F. G. Hayden, University of Virginia
12. Dr. A. Patick, Agouron Pharmaceuticals, Inc., california
13. Dr. K. Shortridge, University of Hong Kong
THANK YOU FOR TAKING THE TIME TO COMPLETE THIS FORM.
PLEASE RETURN IT TO: skriston@wiley.co.uk
---------------------------------------------------------------------------------------
questionnaire:
Review of New Book Proposal
INFECTIOUS ETIOLOGIES OF NEUROPSYCHIATRIC DISORDERS
Edited by S. Hossein Fatemi
IN CONFIDENCE
SUBJECT MATTER OF THE BOOK
Price Pages Illustrations
Approx £75 250 pp Yes
Anticipated Pub Date
December 2003 Hardback
1. Is there, in your opinion, a need for a publication of this type?
2. Do you think that the proposed book would fulfil such a need, if indeed one
exists?
3. Please comment on the content of the book and its scope. Are there any
obvious gaps and/or areas that you would wish to see covered in greater detail?
Have you any other editorial suggestions which you feel might improve the
usefulness and value of the proposed book?
4. Please comment on the author's standing in and contributions to the field.
Are you familiar with the author? Do you think this author is well-suited to
writing the book as proposed?MARKET FOR THE BOOK
5. What do you consider to be the primary markets for this book? What are the
potential secondary markets and areas of possible fringe interest? In addition,
are there any professional organisations, societies, companies or other groups
whose members/employees might be interested in the book? Do you have any
recommendations regarding content that would ensure appeal to the intended
market? In your opinion, is this book primarily a reference, text or monograph?
6. Are there any undergraduate and/or postgraduate courses in the UK, Europe,
the USA or elsewhere for which the book might be adopted as a main course text
or recommended for supplementary reading? Please give details of courses
together with information on texts currently in use which might be considered as
competitors.
7. Do you know of any existing publications on this subject or manuscripts in
preparation which are likely to compete with the book under review? Please
supply details and compare principle features.
ADDITIONAL INFORMATION
8. Could you suggest possible additional referees? (Please provide full
addresses and/or telephone numbers where possible)
9. Are there any additional comments you wish to make concerning the proposed
book?
10. In the event of any discussion of your comments with the author(s) and/or
editor(s), do you have any objection to the disclosure of your identity, or
would you prefer to retain reviewer's anonymity?
Thank you for taking the time to complete this questionnaire.
Once again, many thanks for reviewing this book proposal. Please complete the
details listed below before returning the completed questionnaire to Wiley.
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John Wiley & Sons
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