| Item | Description | Location |
| Antidote | Cures Poison |
PokéMon Mart $100 |
| Awakening | Cures Sleep |
PokéMon Mart $250 |
| Bicycle | Allows faster travel | Cerulean Bike Shop |
| Bike Voucher | Get a free bike | Vermilion City PokéMon Fan Club |
| Burn Heal | Cures Burn |
PokéMon Mart $250 |
| Calcium | Boosts Special Stat on 1 PokéMon |
Celadon Department Store $9,800 |
| Carbos | Boosts Speed Stat on 1 PokéMon |
Celadon Department Store $9,800 |
| Card Key | Opens Silph Co. Doors | Saffron City - Silph Co. |
| Coin | Play Game Corner Slots / Exchange for prizes | Celadon Game Corner |
| Coin Case | Holds up to 9,999 Coins | Celadon City Diner |
| Dire Hit | Boosts Accuracy |
Celadon Department Store $650 |
| Dome Fossil | Used to resurrect a Kabuto | Mt. Moon |
| Elixer | Restores 10 PP for each ability on 1 PokéMon | Various Areas |
| Escape Rope | Escape from current area | PokéMon Mart |
| Ether | Restores 10 PP of one ability | Various Areas |
| Exp. All | Charm to split earned EXP to all PokéMon | Route 15 Lookout Station |
| Fire Stone | Evolves some Fire PokéMon |
Celadon Department Store $2,100 |
| Fresh Water | Restores 50 HP, give to thirsty people |
Celadon Department Store $200 |
| Full Heal | Cures any condition |
PokéMon Mart $600 |
| Full Restore | Cures any condition, restores all HP |
PokéMon Mart $3,000 |
| Gold Teeth | Allows Safari Zone Warden to speak | Safari Zone |
| Good Rod | Used to fish for PokéMon; better than Old Rod | Fuchsia City |
| Great Ball | Used to catch PokéMon; better than PokéBall |
PokéMon Mart $600 |
| Guard Spec. | Protects against special attacks |
Celadon Department Store $700 |
| Helix Fossil | Used to resurrect an Omanyte | Mt. Moon |
| HP Up | Boosts the HP Meter of 1 PokéMon |
Celadon Department Store $9,800 |
| Hyper Potion | Restores 200 HP |
PokéMon Mart $1,500 |
| Ice Heal | Cures Frozen PokéMon |
PokéMon Mart $250 |
| Iron | Boosts Defense stat of 1 PokéMon |
Celadon Department Store $9,800 |
| Item Finder | Used to indicate where hidden items are | Route 11 Lookout Station |
| Leaf Stone | Evolves some Grass PokéMon |
Celadon Department Store $9,800 |
| Lemonade | Restores 80 HP, give to thirsty people |
Celadon Department Store $350 |
| Lift Key | Activates Game Corner elevator | Celadon Game Corner |
| Master Ball | Catches PokéMon 100% of the time | Saffron City - Silph Co. |
| Max Elixir | Restores all PP of 1 PokéMon | Various Areas |
| Max Ether | Restores all PP of one ability | Various Areas |
| Max Potion | Restores all HP for 1 PokéMon |
PokéMon Mart $2,500 |
| Max Repel | Prevents random attacks |
PokéMon Mart $700 |
| Max Revive | Revives 1 PokéMon with full health | Various Areas |
| Moon Stone | Evolves some PokéMon | Mt. Moon, Route 2, Celadon Game Corner, Cinnabar Island Mansion |
| Nugget | Sell at PokéMon Mart for $5,000 | Various Areas |
| Oak's Parcel | Give to Professor Oak for a PokéDex | Viridian PokéMon Mart |
| Old Amber | Used to resurrect an Aerodactyl | Pewter City Back Museum |
| Old Rod | Used to catch the PokéMon Magikarp | Vermilion City |
| Paralyze Heal | Cures Paralis |
PokéMon Mart $200 |
| PokéBall | Used to catch PokéMon |
PokéMon Mart $200 |
| PokéDoll | A doll of Clefairy, Distracts opponents |
Celadon Department Store $1,000 |
| PokéFlute | Wakes up all sleeping PokéMon | Mr. Fuji - Lavender Town |
| PokéDex | Encyclopedia record of all PokéMon you've seen and caught | Prof. Oak |
| Potion | Restores 20 HP for 1 PokéMon |
PokéMon Mart $300 |
| PP Up | Boosts PP meter of 1 PokéMon by 2 | Various Areas |
| Protein | Boosts Attack stat for 1 PokéMon |
Celadon Department Store $9,800 |
| Rare Candy | Boosts the level of 1 PokéMon by 1 | Various Areas |
| Repel | Prevents Random Attacks |
PokéMon Mart $350 |
| Revive | Revives 1 PokéMon with half it's health |
PokéMon Mart $1,500 |
| S.S. Ticket | Used to aboard the S.S. Anne | Bill's Sea Cottage |
| Safari Ball | PokéBall used in the Safari Zone | Safari Zone - Fuchsia City |
| Secret Key | Opens locked Gym Doors | Cinnabar Island Mansion |
| Silph Scope | Reveals Ghosts | Celadon Game Corner |
| Soda Pop | Restores 60 HP, give to thirsty people |
Celadon Department Store $300 |
| Super Potion | Restores 50 HP |
PokéMon Mart $700 |
| Super Repel | Prevents random attack; better than Repel |
PokéMon Mart $500 |
| Super Rod | Used to fish for PokéMon; better than Good Rod | Route 12 |
| Thunder Stone | Evolves some Electric PokéMon |
Celadon Department Store $2,100 |
| Town Map | Map of the PokéMon World | Rival's House - Pallet Town |
| Ultra Ball | Used to catch PokéMon; better than Great Ball |
PokéMon Mart $1,200 |
| Water Stone | Evolves some Water PokéMon |
Celadon Department Store $2,100 |
| X Accuracy | Boosts Accuracy for 1 PokéMon for Battle |
Celadon Department Store $950 |
| X Attack | Boosts Attack for 1 PokéMon for battle |
Celadon Department Store $500 |
| X Defend | Boosts Defense for 1 PokéMon for battle |
Celadon Department Store $500 |
| X Special | Boosts Special of 1 PokéMon for battle |
Celadon Department Store $350 |
| X Speed | Boosts Speed of 1 PokéMon for battle |
Celadon Department Store $350 |
