TS Chat Room friends, this is the Second Posting of my notes from the MEDICAL Symposium at the TSA '98 in DC, I hope they are of some interest or help to someone. Remember that they are just notes, please.

BB

The Scientific Basis of TS bye Dr Harvey Singer, M.D.

WHERE IS IT LOCALIZED?-NEUROANATOMY

Standard Approaches

Physical Exam

Lab studies

Electrophysiology

Neuroradiology

Stimulation Studies

Neuropathology

Frontal sub cortical circuits

Motor Limbic oculomotor prefrontal

Supporting Evidence of a Frontal Subcorticl Circuit Disorder I

SPECT Regional Cerebral Blood Flow

Functional Magnetic Resonance Imag.

BASAL GANGLIA + Thalmus

MRI-Symetry DIFFERENCES left Putamen L. Lenticular-smaller

Reduced Caulate size

Putamen differences- Males have more and bigger differences ***

Corpus Coloss0_carries messages from one side to the other of the brain and has changes

Rostral Body in TS ers is BIGGER

HOW DO YOU GET IT?

GENETIC and ENVIRONMENTAL

Twin Studies 55% for TS com. Ident. Twins

10% for TS " Dizygotic Twins

MZ Twins Variability indica environmental factors

98% of population doesn't carry the gene

2% has one copy of the gent 2% of 2% of the population will get it due to other genes or something environmental