Knife: Crappy, short range, waste-of-time weapon. It is the worst weapon in the game, well to me it is. It takes off hardly any damage to the enemy.
Handgun: Probably one of the most usefull weapons in the game. Good shot range, and realoads fast. You'll use it a lot.
Shotgun: A strong weapon. It is fast and takes off a lot of damage to the enemys. Use it on bosses.
Hunting Rifle: A strong weapon. It has a great accuracy and great range, but it is very slow.
Steel Pipe: This is a slow weapon. It's better than the knife but thats all. Use it on very slow enemys.
Rock Drill: Can only be available if you beat the game. It needs the gas to work. Has a shot range, not very good.
Chainsaw: Can only be available if you beat the game. It also needs gas to be used. It has a short range, and is not very powerfull but it sure is fun to use!
Axe: Is a very fast swinging weapon. It is not very strong but it can stun the enemys giving you time to get away.
HAMMER: Personally my favorite weapon. It's not that slow and it delievers a heavy blow. And when you kill nurses the go into shock! Use it on ground enemys.