When C.E.O. Ozzy Osborn of Oscorp became President of the United States of America, he created a regime that rooted out subversion and weakness. Oscorp created the Variable Engagement Neuro-sensitive Organic Mesh (or V.E.N.O.M.) to empower Ozzy's brutal police force known as the Thunderbolt Department.
Elsewhere, punk-rocker Hobie Brown developed spider-powers due to illegal chemical dumping. He was able to create the Spider Army and fought against Osborn, who eventually fell in battle with them.
Heroes:
Spider-Punk
Captain Anarchy
The Hulk
M.C. Strange
Villains:
Norman Osborn
Adrian Toomes
Kang the Conglomerator
Surf-Annihilus
Villainous Groups:
Thunderbolt Department
Toomestone Records
Annihilation Wave
The U-Foes
The Universal Church of Truth