| Pitcher's Name | W-L | ERA | G | SV | IP | H | ER | HR | BB | SO |
| Eddie Plank | 8-14 | 2.13 | 31 | 0 | 249.2 | 186 | 59 | 14 | 30 | 147 |
| Rube Waddell | 10-14 | 1.80 | 34 | 0 | 255.2 | 194 | 51 | 10 | 37 | 154 |
| Chief Bender | 13-10 | 1.22 | 33 | 0 | 235.2 | 125 | 32 | 12 | 13 | 71 |
| Jimmy Dygert | 15-11 | 1.19 | 34 | 0 | 264.0 | 142 | 35 | 11 | 35 | 95 |
| Jack Coombs | 17-8 | 0.99 | 38 | 0 | 273.0 | 110 | 30 | 13 | 20 | 49 |
| Rube Vickers | 9-5 | 2.73 | 31 | 0 | 73.1 | 25 | 10 | 6 | 3 | 4 |
| Bill Bartley | 3-4 | 1.91 | 18 | 6 | 33.0 | 12 | 7 | 4 | 1 | 2 |
| Totals | 75-66 | 1.46 | 143 | 6 | 1384.1 | 794 | 224 | 70 | 139 | 522 |
