Dr.Victor Fries was one of Gothcorp's most brilliant scientists and cryogenic researchers, however he was unable to cure his wife Nora of a deadly disease. His research in cryogenics was eventually cut off by the bureaucrats at Gothcorp. His experiment to create a cryogenic freezing chamber to house his wife until a cure could be found was interrupted by Ferris Boyle, C.E.O. of Gothcorp, and his security guards.

Driven by hatred over the destruction of his life and maddened by his condition he pursues a life of crime and vengeance by destroying Ferris Boyle and crippling Gothcorp. His plans are stopped by Batman. Mr.Freeze becomes bent on destroying Batman since he blocked his mission for revenge. He is a quiet, but dangerous adversary. Mr.Freeze is an angry and saddened man, who is sentenced to Arkham Asylum when apprehended. A special cell is designed to maintain his need for a frozen environment. He is alone and his only motivation comes from his wife's music box, which he holds as his last piece of the happiness he once had. He is viewed as an loner by the rogues gallery, and generally does not hold alliances with any of the other inmates of Arkham. Batman knows he is a dangerous adversary, and that the traumas that have occurred in Mr.Freeze's life are scars which will never heal.