The Mutates were beings who were human that were genetically alterd. They were spliced, with bat, jungle cat, and eel DNA to become gargoyle like creatures that would believe the gargoyles were the enemies and that Xanatos was their friend. They did learn the truth and decided to move into the an old abandoned lab beneath the sewers and watch over the homelss who live there.

Talon, once known as Derek he is Elisa's partner. He was a bit reluctant to be the leader, but he learned he had too for the sake of Maggie and Claw. After fighting Thailog he deicded he should take in the clones and teach them to think for themselves.

Fang, This trouble maker tried to use brute force to be the leader of the mutates but instead became the prisoner.

Maggie Reed, originaly a homeless girl from Ohio she hated what was done to her and was bent on trying to find a cure. She later accepted her new form as she learned to love Talon

Claw, This mute mutate wanted to be human again as much as Maggie. He was first bullied by Fang but rebeled against him.