| | San Francisco 49ers Seattle Seahawks | October 11, 8:00 PM at Seattle, Washington |
| | Jacksonville Jaguars Chicago Bears | October 13, 9:00 AM at London, England |
| | Arizona Cardinals Green Bay Packers | October 13, 1:00 PM at Green Bay, Wisconsin |
| | Cleveland Browns Philadelphia Eagles | October 13, 1:00 PM at Philadelphia, Pennsylvania |
| | Houston Texans New England Patriots | October 13, 1:00 PM at Foxborough, Massachusetts |
| | Indianapolis Colts Tennessee Titans | October 13, 1:00 PM at Nashville, Tennessee |
| | Tampa Bay Buccaneers New Orleans Saints | October 13, 1:00 PM at New Orleans, Louisiana |
| | Washington Commanders Baltimore Ravens | October 13, 1:00 PM at Baltimore, Maryland |
| | Atlanta Falcons Carolina Panthers | October 13, 4:00 PM at Charlotte, North Carolina |
| | Detroit Lions Dallas Cowboys | October 13, 4:00 PM at Arlington, Texas |
| | Pittsburgh Steelers Las Vegas Raiders | October 13, 4:00 PM at Paradise, Nevada |
| | Los Angeles Chargers Denver Broncos | October 13, 4:00 PM at Denver, Colorado |
| | Cincinnati Bengals New York Giants | October 13, 8:00 PM at East Rutherford, New Jersey |
| | Buffalo Bills New York Jets | October 14, 8:00 PM at East Rutherford, New Jersey |