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Structural of Mucin Glycopeptide
The above molecule is the structual
of amucin glycopeptide. The mucine glycopeptide is study on synthetic
glycopeptide bearing clusterd -mono, -di,-tri, and hexasaccharide
glycodomains......
The structuralcharacteristics of a mucin glycopeptide motif
derivedfrom the N-terminal fragment STTAV of the cell surface glycoprotein CD43 have been investigated by NMR. In this study, a series of molecules prepared by total synthesis were examined, consisting of the peptide
itself, three glycopeptides having clustered sites of alpha-O-glycosylation on the serine and threonine side chains
with the Tn, TF, and STF carbohydrate antigens, respectively,
and one with the beta-O-linked TF antigen. Additionally, a glycopeptide having the sequence SSSAVAV, triglycosylated
with the Le(y) epitope, was investigated.
NMR data
for the tri-STF-STTAV glycopeptide were used to solve
the structure of this construct through restrained molecular dynamics calculations. The calculations revealed a
defined conformation for the glycopeptide core rooted in the interaction of the peptide and the first N-acetylgalactosamine residue. The similarity
of the NMR data for each of the alpha-O-linked glycopeptides demonstrates that this structure persists for
each construct and that the mode of attachment of
the first sugar and the peptide is
paramount in establishing the organization of the core. The core provides a common framework on which a variety of glycans may be displayed. Remarkably,
while there is a profound organizational
effect on the peptide backbone with
the alpha-linked glycans, attachment via a beta-linkage has little apparent consequence
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