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The improvement in lipids (HDL-cholesterol and triglycerides) was demonstrated to be partially independent from weight loss, implying a direct effect of the drug on these important metabolic cardiovascular risk parameters.

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To put this another way, the Kaplan-Meier curves kept separating throughout the 2.

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For instance, it's well established in animals that drugs that stimulate cannabinoid receptors can limit brain damage in trauma and stroke.

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Wolfe also pointed to what he called the paucity of information on the effect of using the drug over the long term.

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