The Sound of Urchin
The Sound of Urchin is a great unknown rock band.
Flickerstick
You may have seen Flickerstick on WH1's "Bands on the Run". Check out their great sound!
Gov't Mule
Gov't Mule has a great retro-blues rock sound. They are awesome, definitely check them out.
Chris Whitley
Chris Whitley has a really great sound and uses some pretty rare instruments. He is signed to Dave Matthew's record label, so he can only be the best.