Federal Route 54 runs southwest-northeast through a small section of west-central Illinois. It enters the state from Missouri through Pike County to terminate at Interstate 72/US36.
Intersections from SW to NE:
US54 enters Illinois near Louisiana, Missouri
IL106 joins from the west, west of Pittsfield
IL106 leaves to the east at Pittsfield
US54 ends at I-72/US36. North of I-72/US36, US54 becomes IL107.
Pittsfield is the only Illinois town that US54 passes through.