Hypothesis on Disease and Infections Developing Resistance to Antibiotics
This is a work in progress. More will be posted asp.
Abstract:
The physics of several esoteric disciplines are given a general overview, as they apply to Western medicine. It is between the crevices of the esoteric fields of study that the majority of unknown influences to various areas of concern are concealed.
One example are the physics involved in the heating ventilation and air conditioning trade in an open circulating system. And the use of magnetic water treatment to inhibit calcium crystal formation. When the technology is properly applied to a boiler or cooling tower, scale formation (a source of recontamination from microbes) are not only reduce, but removed. This phenomena has been studied by NASA and is applicable for use in certain medical conditions, the prevention of the development of drug resistance and improved efficiancy of antibiotic therapies.
The cumulative effects of toxic chemicals on the development of drug resistance and their negative effects on the immune systems ability to eradicate infections, are also explored. As are the potential effects from various influences on the accuracy of the PCR test.
The Physics of an open circulating system, as applied to modern medicine. With implications on the accuracy of PCR testing, the development of antibiotic resistance and various chronic disorders. Specifically, prostatitis.
The formation of calcium based scale deposits in an open circulating system, are well known to be a cause of recontamination. In fact, the water system in Washington DC had to be replaced because of such deposits as a factor in recontanination of the tap water, with E. coli. In a boiler or cooling tower there are two well known factors that contribute to the formation of such deposits. One is the balance of the pH and the other is the total dissolved solids (TDS). When those factors are adequately addressed, the use of magnetic water treatment (as studied by NASA) has been shown to inhibit calcium crystal formation. "Magnetic treatment of water is an effective method for prevention or drastically reducing the formation of scale or corrosion, with out the use of chemicals. The theory is discussed together with case studies in some published works (4). It has also been reported that the use of EMF therapy can aleviate conditions such as prostatitis (8). But a better understanding of the physics involved should obtain more consistant results, if applied.
How ever, the environment of the human body does differ in certain regards. One of which is the manner in which the body balances the pH of the blood. The pH has been shown to have a direct influence of the oscillation of the DNA membrane (5, pages 1979, 1980, 1981, 1982). Therefore, the manner in which the human body balances the pH is of extreme importance, but poorly understood by many doctors and researchers. There also appears to be a fundamental factor in the accuracy of the PCR test, concealed with in the general operating procedure of this. Not of the test itself. But rather the ability of a given microbe (such as a mycoplams) to proliferate in a given "internal environment". Because of the greater preponderence of the mycrobe, the PCR test may be able to detect it more often, under such circumstances. But this does require a better understanding of the "internal environment", first.
The work of Dr. Morter does reveal some of these factors. The human body needs a "pH reserve" of certain chemicals to properly balance the pH. When this reserve is depleted, the body responds by using calcium to balance it (6). This accumulates and causes a hight concentration of the Total Disolved Solids (TDS) in the circulatory systems. Because some microbes (such as mycoplasma's) are not very hearty, it appears that the condition of it's environment (calcium content) should be a factor in it's proliferation. And therefore the PCR tests ability to detect it. I am basing this hypothesis on the variance of the structural integrity of the internal environment of the body. This particular perspective of the internal environment can also be a proposing factor in prostatitis (7) and the formation of calci.
__________________________________________________________________
1
SLS also maintains residual levels in the brain, heart, liver, and lungs from skin contact. (Journal of the American College of Toxicology; V. 2, No. 7.) Propylene glycol also is shown to be absorbed through the skin with studies showing systemic retention throughout the body. (References: Home Brewed Cancer, Nerwork News and Publications, 1997 3710 Longview Dr., Atlanta, GA 30341.)
2
Magazine: PEST CONTROL; APRIL 2000 Section: Cockroach Control Title: WHAT MAKES ROACHES RESISTANT?
3 Magazine: BLACK ELEGANCE; JUNE 2000 Section: Technology Update FINALLY A `CURE' FOR BAD BREATH!
Reference Material is posted at - https://www.angelfire.com/in/paradigms/arh.html
To:
Carol A. Lee, Esq.
President and CEO
1201 K Street, Suite 1050
Sacramento, CA 95814
(916) 551-2550
cmafoundation@calmed.org
Alliance Working for Antibiotic Resistance
http://www.aware.md/
The three reports that are attached show a correlation with drug resistance
SLS, and pesticides. It is worth noting that phthalates have been found in
many American's by the CDC -
#1 SLS PRESTONE SHAMPOO? The main ingredient in that antifreeze you put in your car radiator is propyelene glycol. It is also one of the ingredients in many mass marketed shampoos (read the labels). Also, usually one of the first ingredients listed on most shampoos is Sodium laureth sulfate (also sodium lauryl sulfate) or SLS, which is routinely used in clinical studies to irritate skin tissue) and is a harsh (caustic) detergent used in concrete floor cleaners, engine degreasers, and car wash detergents, SLS is a favorite ingredient of most toothpaste manufacturers (it creates great suds in your mouth). Problem: SLS has been found to induce mutations in bacteria and it is capable of changing the information in genetic material found in cells. (Higughi, Arayaand Higughi; School of Medicine, Tohoku University; Sendai 980, Japan). SLS also maintains residual levels in the brain, heart, liver, and lungs from skin contact. (Journal of the American College of Toxicology; V. 2, No. 7.) Propylene glycol also is shown to be absorbed through the skin with studies showing systemic retention throughout the body. (References: Home Brewed Cancer, Nerwork News and Publications, 1997 3710 Longview Dr., Atlanta, GA 30341.)
#2
Magazine: PEST CONTROL; APRIL 2000
Section: Cockroach Control
WHAT MAKES ROACHES RESISTANT?
-----------------------------
Insecticide resistance, which is defined as a genetic change that
results in control failure in the field[4], is one of the most important
problems facing entomologists today. There are more than 500 arthropod
species that have developed resistance to insecticides, and that number
is growing at an exponential rate[5]. Because of the recent attention
given to German cockroach (Blatella germanica) allergens and asthma,
let's take a look at its resistance mechanisms.
Insects exhibit three physiological insecticide-resistance mechanisms,
including decreased cuticular penetration, target-site insensitivity and
enhanced metabolism. Although one mechanism is sufficient for resistance
to occur, several are usually at work known as multiple resistance.
This is typical of resistant German cockroach populations.
Decreased penetration-- To be effective, insecticides must reach their
target site in a lethal dose. Thus delaying the rate of insecticide
penetration through the cockroach's outer covering is an important
mechanism of resistance. Delayed penetration reduces the rate of
insecticide entering the insect, which provides time for detoxification
mechanisms to take effect. Alone, this mechanism yields only low levels
of resistance[3]. However, when present with other resistance mechanisms,
it may contribute significantly to insecticide resistance.
Target site insensitivity-- Although it's a simple mechanism, target
site insensitivity is often the most difficult to understand.
Insecticide resistance may result from modification of the toxicant's
target site (the place within the insect where the insecticide binds and
exerts its toxic effect). In other words, a resistant insect's target
site (usually a protein of some sort) is slightly different from the
majority of the insecticide-susceptible population. Such modifications
may result in reduced sensitivity to the toxicant.
One important target site modification resulting in insecticide
resistance is modification of the voltage-gated sodium channels present
in nerve cells. The mutation of these sodium channels may result in
resistance to pyrethroids (and DDT), and is known as knockdown
resistance (KDR).
Pyrethroids and DDT prevent nerve cells from being turned off. This is
why pyrethroid-poisoned insects twitch uncontrollably they are unable
to shut down poisoned nerves. Therefore, sodium channel modification may
prevent or reduce insecticide binding and prevent their toxic action.
KDR appears to be a common mechanism of pyrethroid resistance in the
German cockroach[1].
Enhanced metabolism-- Increased metabolism of insecticides leading to
the formation of less-toxic products (that is, detoxification) is the
most common and important mechanism of insecticide resistance in
insects. The primary goal of detoxification reactions is to create more
water-soluble products from hydrophobic substrates to facilitate
excretion.
Resistance Studies
A common observation made by pest management professionals (PMPs)
after an initial clean out for German cockroaches is that a disproportionate
number of nymphs survive the treatment, compared to adults. Several
years ago, the Center for Medical, Agricultural and Veterinary
Entomology conducted toxicity tests against different stages to
determine whether this observation had any physiological basis, and, if
so, to examine the mechanism or mechanisms responsible for it[2].
The tests showed that the latter (fourth, fifth and sixth) instars were
significantly more tolerant of bendiocarb, chlorpyrifos and cypermethrin
than the adult males or females.
The mechanism responsible for this stage-dependent effect was pursued by
using the carbamate propoxur. Interestingly, when latter-instar nymphs
were pretreated with piperonyl butoxide (PBO), an inhibitor of
cytochrome P450 monooxygenases, the differences in toxicity between
adults and nymphs were eliminated. This result strongly indicated that
enhanced detoxification by cytochrome P450 monooxygenases was
responsible for the stage-dependent enhanced tolerance.
Furthermore, it was later discovered that propoxur metabolism was
greatest in the cockroach fat body (part of its anatomy that stores
energy). The latter-instar nymphs possess considerably larger quantities
of fat body compared with the adult male. Therefore, it was concluded
that nymphs are more tolerant of propoxur because they possess more
enzyme capable of detoxifying the insecticide compared with adults.
From a management standpoint, synergized formulations would be expected
to negate the detoxification enzyme differences in susceptibility
between stages.
An evaluation of insecticide resistance levels and mechanisms among
German cockroaches taken from different locations in Florida, Georgia
and California was recently conducted. Insecticide resistance was
observed in all strains toward some organophosphates (OPs), carbamates
and pyrethroids. It is worth noting that the most resistant populations
were those taken from food preparation areas.
Note: "food preparation areas" denote the use of more SLS from cleaning. The cumulative effects of various chemicals needs to considered. -
Resistance was greatest toward the pyrethroids and lowest toward the OPs
and carbamates, which is probably a reflection of use patterns. In other
words, pyrethroids have been used extensively for German cockroach
control over the past decade, resulting in greater selection toward
pyrethroid resistance.
Although resistance was noted for all strains toward OPs, carbamates and
pyrethroids, no apparent cross-resistance extended toward
hydramethylnon[7]. Among all field strains evaluated, no physiological
resistance toward hydramethylnon was detected.
Interestingly, 85 percent of all strains evaluated possessed a mutation
associated with KDR that is a form of target site insensitivity[1]. This
result also indicates that intense selection pressure with pyrethroid
insecticides has occurred. Synergist bioassay data indicated that
enhanced detoxification was also an important mechanism of resistance in
many of these strains.
Behavioral Resistance
This discussion has primarily been concerned with physiological
resistance mechanisms. However, behavioral modification may also be
considered an insecticide resistance mechanism that can reduce effective
control in the field. Behavioral resistance may be defined as "evolved
behaviors that reduce an insects exposure to toxic compounds"[6]. For
example, an insect capable of avoiding an insecticide would obviously be
more difficult to kill in the field.
Arena tests were conducted against six different populations of German
cockroach that exhibited varying levels of physiological resistance to
pyrethroid insecticides (fivefold to 56-fold) to assess the possible
contribution of behavioral resistance mechanisms (Valles). Basically, 25
adult male German cockroaches from each population were tagged with a
different letter, which was glued to their pronotum. The cockroaches
were placed into a 1.25-meter-square arena with food, water and
harborage, and allowed to acclimate for 24 hours. A single piece of 4.5-
square-inch glass was treated with a wettable powder pyrethroid
formulation and placed randomly along an edge in the arena. Cockroaches
walking on the glass were monitored by videotape for a 12-hour period,
after introduction of the insecticide-treated glass. Mortality in the
arena was recorded 12 hours after treatment and the videotape was
reviewed at a later time. The proportion of cockroaches walking on the
treated glass, the total number of visits made and the total duration on
the treated glass were tallied and compared with an insecticide-
susceptible strain.
Complete control (100 percent mortality) was achieved for the
insecticide-susceptible strain. However, significantly lower mortality
was observed for the six insecticide-resistant strains.
Videotape analysis indicates that the visitation rate was lower in the
insecticide-resistant populations, although no differences were observed
in the total duration between populations. This data indicate that
although the insecticide-susceptible cockroaches visited the treated
glass more frequently, the total time on the insecticide residue was the
same among the insecticide-resistant and -susceptible cockroaches.
Although not definitive, the data tend to indicate that behavior is
different between the insecticide-susceptible and -resistant
cockroaches. The susceptible cockroaches used in our study are
apparently more active than the resistant field cockroaches. However,
because the total amount of time spent on the insecticide-treated glass
and the proportion of cockroaches walking on the insecticide-treated
glass were the same for resistant and susceptible cockroaches, there
does not appear to be any avoidance behavior exhibited by the resistant
cockroaches.
Author's Note: Mention of a proprietary product does not constitute an
endorsement or recommendation for use by the USDA. The author wishes to
thank Charles Strong for technical assistance.
PHOTO (COLOR): Resistant and non-resistant German roaches were tested
for mortality rates from a wettable powder pyrethroid.
References
1. K. Dong, S. M. Valles, M. E. Scharf, B. Zeichner, G. W. Bennett.
Pesticide Biochemistry and Physiology 60, 195 (1998).
2. P. G. Koehler, C. A. Strong, R. S. Patterson, S. M. Valles. Journal
of Economic Entomology 86, 785 (1993).
3. F. W. Jr. Plapp and R. F. Hoyer. Journal of Economic Entomology 61,
1298 (1968).
4. R. M. Sawicki, Combating Resistance to Xenobiotics; Biological and
Chemical Approaches, M. G. Ford, D. W. Holloman, B. P. S. Khambay, R. M.
Wawicki, editors. (Ellis Horwood, Chichester, England, 1987), pp. 105-
117.
5. J. G. Scott, CRC Handbook of Pest Management in Agriculture, D.
Pimentel, Editor. (CRC Press, Boca Raton, ed. 2nd, 1991), pp. 663-677.
6. T. C. Sparks, J. A. Lockwood, R. L. Byford, J. B. Graves, B. R.
Leonard. Pesticide Science 26, 383 (1989). 7. S. M. Valles and R. J.
Brenner. Journal of Economic Entomology 92, 617 (1999).
~~~~~~~~
By Steven Valles, Contributor
Dr. Steven Valles is a research entomologist at the Center for Medical,
Agricultural and Veterinary Entomology in the Imported Fire Ant and
Household Insects Research Unit, Gainesville, Fla.
Much of this material has been posted for the intended use of research and educational
purposes.
Copyright laws still apply.
Copyright of Pest Control is the property of Advanstar Communications
Inc. and its content may not be copied without the copyright
holder's express written permission except for the print or
download capabilities of the retrieval software used for
access. This content is intended solely for the use of the
individual user.
Source: Pest Control, Apr2000, Vol. 68 Issue 4, p58, 3p, 1c.
Item Number: 3037007
#3
Magazine: BLACK ELEGANCE; JUNE 2000
Section: Technology Update
FINALLY--A `CURE' FOR BAD BREATH!
---------------------------------
For years, the cause of chronic bad breath has been misdiagnosed, but a
dentist's research has led to Thera Breath(TM), a dramatic treatment
system that works naturally and effectively.
These days, people spend a great deal of time or, their health and
fitness. Exercise, nutrition and an emphasis on general wellness are
important to people not only for medical reasons, but for social ones as
well. Everyone wants to feel and look their best. Unfortunately, many
people around the world suffer from a condition that cannot be cured at
a health club, spa or even a hospital: chronic bad breath.
It is estimated that over 80 million people worldwide suffer from bad
breath, or halitosis. In the past, treatment has consisted of masking
the odor with mouthwashes or mints, flooding the mouth with alcohol-
based rinses, or the latest craze, popping pills that claim to cure the
problem in the stomach. None of these treatments work, because halitosis
is caused by bacteria on the back of the tongue and upper throat that
produce sulfurous gases. The way to stop bad breath is to stop this
process, and this is the secret behind the revolutionary Thera Breath(TM)
system.
You're the last to know. Because halitosis originates in the mouth, it
is virtually undetectable by your own sense of smell. You may notice a
bitter, sour taste in your mouth or a whitish coating on the back of
your tongue, but you generally find out there's a problem when a family
member, friend or co-worker brings it to your attention. At that point,
you need an effective, long-lasting and easy-to-use method of
eliminating the problem. Without proper treatment, chronic bad breath
can lead to a loss of confidence and self-esteem, and it can even result
in depression. The problem can adversely affect your marriage, social
life, career and relationships with family members. What's needed is a
quick and effective treatment that works naturally with no side effects.
A scientific solution. As a dentist with a degree in bacteriology, Dr.
Harold Katz has been keenly aware of the widespread nature of this
problem. It was not until his daughter came to him about her halitosis,
however, that he began to research the problem in earnest. His studies
led him to an amazing discovery about the source of bad breath: it does
not originate in the digestive system, and the food you eat has no
direct effect on your breath.
Certain foods, however, contribute to the production of sulfurous gases
in the back of the mouth. Acids in coffee and proteins in dairy products
exacerbate the problem. Mints and mouthwashes intended to mask or
prevent bad breath actually worsen the condition because sugar and
alcohol dry out the mouth. Many common medications for everything from
high blood pressure to depression have the same drying effect, resulting
in the formation of odorous gases. Mucous from post-nasal drip contains
dense proteins that are full of sulfur. Some treatments for halitosis
contain Sodium Lauryl Sulfate, which can cause canker sores. The only
effective means of eliminating the sulfur gas production is to introduce
oxygen to the bacteria, causing them to produce tasteless, odorless
sulfates.
Effective, safe and natural. At his California Breath Clinic, Dr. Katz
has perfected a five-step program for treating halitosis. By using these
products on a regular basis, chronic halitosis sufferers can end their
problem. The TheraBreath system eliminates the problem of bitter or sour
taste in the mouth, improves general periodontal health and will even
whiten teeth. Unlike mouthwashes that are flavored heavily or designed
to taste like medicine, TheraBreath has a mild spearmint flavor that
tastes great and creates pleasant, neutral breath. It contains no SLS
compounds, so you will not suffer from an increase in canker sores or
any other side effects. These products are all-natural and simply
introduce a greater amount of oxygen into the mouth's chemistry.
Try it risk-free. The TheraBreath System is an effective, safe and
easy-to-use solution to a troubling problem, but don't just take our
word for it. Try this product for yourself with our risk-free home
trial. If you are not fully satisfied, just return it within 30 days for
a full refund.
HOW IT WORKS
We all have natural bacteria that live on the back of the tongue and aid
in digestion. Under certain conditions, these bacteria will break down
proteins and transform them into sulfides, which create odor and bad
taste.
Oxyd-VIII(TM) (A Proprietary Oxygenating Formula), the active ingredient
in TheraBreath, transforms these odor-causing sulfides to sulfates,
which have no taste or odor.
Dear Dr. Katz,
Our son has had a breath problem for years. He tried mouthwashes and
mints. We took him to doctors and dentists, and even had his tonsils
removed. Nothing worked, until he tried your product. I am so thankful
and thrilled that you found the solution to his problem. You'll never
know how much you changed his life!
-- M.C., Los Angeles
~~~~~~~~
By Jason Williams
Posted for educational and research purposes. Copyright laws still apply.
Copyright of Black Elegance is the property of Starlog Press Inc. and
its content may not be copied without the copyright holder's
express written permission except for the print or download
capabilities of the retrieval software used for access. This
content is intended solely for the use of the individual user.
Source: Black Elegance, Jun2000 Issue 129, p60, 1p.
Item Number: 3188342
4 : Magnetic Treatment of Water,Professor C. Jack Quinn, Purdue University, Fort Wayne,
Ind., "Magnetic treatment of water is an effective method for prevention or drastically
reducing the formation of scale or corrosion, with out the use of chemicals. The theory is
discussed together with case studies.
5 : Oscillation of membrane potential in ion-complex membranes of DNA and
hexamethylenediamine. Akon Higuchi. J. Chem. Sve. Faraday Trans. 1998, Vol. 94(14),
pages 1979, 1980, 1981, 1982.
6 : pH – Your Potential Health, By Dr. Regan Golob, DC. The following article is from a series written by
Dr. Regan Golob for the Dynamite® Specialty Products monthly newsletter.
7 : Journal of Clinical Microbiology, June 1998, pages 1646-1652, author John Krieger 8 : Author: Zaslavskii-A-Oi. Markarov-G-S. Gelis-IuS. Title: Electromagnetic urological stimulator. Source: Med-Tekh. 1997 May-Jun. (3). P 42-3. Journal Title: MEDITSINSKAIA TEKHNIKA.