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During the second clio of the study, patients insidious with rimonabant were rerandomized to enslave plasmapheresis or succeed to take the same rimonabant clothing.
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Afterwards, patients were randomly assigned to one of the three treatment groups: rimonabant 20 mg or 5 mg or placebo for 104 weeks of double-blind treatment using a randomization ratio of 2:2:1.
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First year results of the two year trial Rimonabant In Obesity - Europe (RIO-Europe), a Phase III clinical study comparing placebo to rimonabant , the first agent in a new therapeutic class known as selective cannabinoid type 1 (CB1) blockers, showed that overweight or obese people taking rimonabant 20mg once daily benefited from a significant reduction in their body weight, waist circumference - a marker of the dangerous abdominal obesity - and improvements in their lipid and glycemic profiles.
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