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Abstract of articles from |
| Indian Journal of Tuberculosis | |
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Vol 55 
No 4Oct 2008
ISSN 0019-5707 |
Original articles
- Psychosocial dysfunction:Perceived and enacted stigma among tuberculosis patients registered under Revised Nationl Tuberculosis Control Programmme
- Study of relapse and failure cases of Cat I retreated with Cat II under RNTCP -An 11 year follow-up
- Screening of bulk drug samples and anti-tuberculosis products for the presence of therapeutically less active diasteriometric(R,S)form of Ethambutol dihydrochloride
- Treatment outcome of neuro-tuberculosis patients put on DOTS-An observation study from the field
- Status report on RNTCP
- Lupus vulgaris and tuberculosis verrucosa cutis(TBVC-A clinical,pathological epidemiological study of 71 cases
Case reports
- Disseminated tuberculosis manifesting as chronic Pancreatitis
- Tubercular hepatic abscess-A rare presentation
First Joint International conference of South East Asia Region(The Union) and 63rd National conference on Tuberculosis &chest diseases(SEAR-NATCON 2008)
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Psychosocial dysfunction:Perceived and enacted stigma among tuberculosis patients registered under Revised Nationl Tuberculosis Control Programmme
- Over 1.7 million pulmonary TB suspects were examined
- 254127 sputum positive cases were diagnosed
- 4121766 TB cases were registered for treatment
- The annual case detection rate is 144 cases per 100000
- 1170100 new sputum positive were registered
- 61273 were new extrapulmonary TB(EPTB) cases
- 76978 were smear positive retreatment cases
- 23348 were rtreatment others
- The treatment success among the new smear positive PTB cases registered in the second quarter 2007 was 86%.the sputum conversion rate and cure rate among the new sputum positive cases were 89% and 84% respectively.Altough the default rates among NSP (6.3%),NSN(7.8%)and re-treatment cases(15.3%)are showing a declining trend,the current rates continue to be an area of concern which the programme managers at all levels must focus upon.
J.Jaggarajamma,Rajeswari Ramachandran,Nirupa Charles,V.Chandrasekaran,M.Muniandy and Sudha Ganapathy.
objective;To examine the perceived and enacted stigma experienced TB patients and the community .
Method : We interviewed 276 TB patients registered for treatment during January - MARCH 2004 in government health facilities of two Tuberculosis Units of South India . Data on perceived and enacted stigma were collected after two months of starting treatment , using a semi - structured interview schedule .In addition , four focus group discussions were conducted among directly observed treatment [DOT] providers and community members . narrative summaries were also taken down to collect additional qualitative information.
RESULTS ; of the 276 patients 190 [69%] were males . There was no significant differance between the genders in relation to social stigma.Perceived stigma was higher than enacted stigma in both genders and signjficantly higher among males(low self esteem(p< 0.05)Change of bevaviour of community(p< 0.05)ashamed to cough in front of othes(p<0.05)
Conclusion: Considering the social aand emotional impactt of the disease,it is essential to adopt support startegies to enahance acceptance and for a successful health programme.
[Indian J Tuberc 2008;55:179-187]
Study of relapse and failure cases of Cat I retreated with Cat II under RNTCP -An 11 year follow-up R.K.Mehra,V.K.Dhingra,Aggarwal Nishi and R.P.Vasisht
Objective: To analyse the treatment outcome of Cat I smear positive relapse and failure cases and theeir fate when treated with Cat I regimen under RNTCP.
Methods: All Cat I smear positive relapse and faillure TB patients trated with cattegort II regimen from 1994 to 2005 in a chest clinic of Dehli were analysed in this retrospective study.The retreatment outcome data for relapse and faileure cases of Cat I when treated with CatII regimen was reviewed.
Results: The study popopulation included 5576 registered as CAT I sputum positive cases in Gulabi Bagh chest clinic from 1994 to 2005.A total 0f 190 (3.4%)failed on Cat I regimen.Further out of 4905 (87.9%)successfuly treated Cat I patients,442(9%)presented as relapses.The treatment success rate for relapse and failure cases of Cat I when subsequrntly treated with Cat II regimen were 76.4% and 48.8% respectively with a significantly higher failure rate(27.6%)Among Cat I failures subsequently treated with Cat II regimen
Conclusion: The failre cases of Cat 1 subsequently treated with Cat II were observed to have a significantly lower success rates(p<0.05)as compared to relapse cases.The need for reappraisal of Cat II retreatment regimen for failure cases among Cat I is suggested.(BR> Indian J Tuberc 2008;55:188-191
Screening of bulk drug samples and anti-tuberculosis products for the presence of therapeutically less active diasteriometric(R,S)form of Ethambutol dihydrochloride
Bhagwat Prasad,Vijay Kumar,Hemant Bhutaniand Saranjit Singh
Backgrund: The presnt study was carried out to screen various Ethambutol dehydrochloride(EB2HCI)bulk drug samples and anti-tuberculosis(Anti-TB products for the presence of less active(RS)-EB2HCI
Methodology: Samples of pure EB2HCI were received gratis from various companies and the formulations were procured from local market,and also from a directly observed treatment short-course(DOTS)centre.Some products available in the institute from Global Drug Facility were also included in the study.In total 5 API samples and 35 formulations containing EB2HCI were investigated.These were subjected to evaluation for the presence of (R.S).EB2HCI using a previously published differential scanning colorimetric method.The thermograms were recorded between 250C and 2500C at a rate of 100C/min.
Results: 1 API sample and formulations were found to contain(R.S)-EB2HCI up to an extent of 30-100%.One of the DOTS centre supply was also found to contain -97% of the less active iomer
ConclusionThe presence of herapeutically inactive form of EB2HCI from 30-100% in approximately 30% of the products in the local market is an alarming finding,which mean low quality anti-TB product are in circulation.The same may be contributory to the developing resistance of the drugs against the Mycobacterium Indian J Tuberc 2008,55,192-198.
Treatment outcome of neuro-tuberculosis patients put on DOTS-An observation study from the field
K.Venugopal,P.R.Srilatha,Sairu Philip and Vijay Kumar
Background: Effectiveness of intermittent short course chemothearapy for neuro Tuberculosis has not been well studied.There are only few reported studies on this issue in the world literature under field conditions.Neurologists all over India are reluctant to accept Directly Observed Short course for Neuro tuberculosis since its introduction in India Aim: Assessingg effectiveness Revised National TB Control programme(RNTCP-DOTS).Regimens among neuro tuberculosis patients registered under the programme.
MethodsAll the neuro tuberculosis patients referred to RNTCP for treatment were included in the study.Study population included only those patients diagnosed at higher centre and referred to RNTCP during the period January-December 2002.Alappuzha District Diagnostic Algorithm as per RNTCP guidelines was strictly followed and treatment outcome and follow up status were taken from tuberculosis register.No paediatric age group was included in the study. Results: A total of 32 cases registered for DOTS regimen were included in the study of whom 29 completed the treatment and all were asymptomatic at the end of treatment(85%).All patients received treatment as DOTS,but only 70% received actual DOTS.All patients were given 9 months intermittent regimen as per RNTCP guidelines.Five patients died during the treatment(14%).This result shows that DOTS under field programme condition are efficient in curing neurotuberculosis.
Conclusion: Good result was obtained with intermittent short course chemotherapy under programme condition in neurotuberculosis Indian J Tuberc 2008,55,199-202
Lupus vulgaris and tuberculosis verrucosa cutis(TBVC-A clinical,pathological epidemiological study of 71 cases L.Padmavathy,L.Lakshmana Rao,T.Pari,N.Ethirajan and B.Krishnasamy
Background: The epidemiological aspects and diagnostic problems encountered in a rural set up are largely unknown.The present study on cutaneous tuberculosis encompassing clinical,pathological and epidemiological aspects was undertaken at Rajah Muthiah Medical college and hospital(RMMC and H)a teaching hospital mainly catering to the health needs of a predominantly rural population from villages and hamlets around Chidambaram,a taluk headquarters located in Cuddalore district of Tamilnadu.
Material and Methods: During the period of study,5744 cases(82%)of pulmonary tuberculosis and 1261(18%)of extrapulmonary tuberculosis were encountered.Cutaneous tuberculosis accounted for 117(1.6%)of tuberculosis cases.
Results: Of the 71 patients with cutaneous tuberculosis,39 had lupus vulgaris and 32 with TBVC.Lupus vulgaris was more prevalent with male preponderance.The maximum incidence was seen in the second decade of life.Both LV and TBVC showed a male preponderance,M:F ratio being 3.2 and 2.1 in LV and TBVC respectively.A majority of patients with LV (27 cases, ,69.2%)and TBVC(31 cases 96.8%)manifested with a single site of involvement.Lower extremities were more commonly involved among patients hailing from poor econoic strata who were not habituated to the use of footwear while working outdoors.Overcrowding was also a contributing factor.The relationships between BCG vaccination and Mantoux test with cutaneous tuberculosis,association with pulmonary tuberculosis in addition to the underlying predisposing socio-economic factos are discussed
Indian J Tuberc 2008,55,203-209
During the first quarter 2008
Disseminated tuberculosis manifesting as chronic Pancreatitis
R.Avasthi,S.C.Chaudhary and Piyush Jain
Pancreatic involvement in tuberculosis is known but uncommon. The clinical manifestation may vary from painless obstructive undice due to pancreatic mass(cyst or abscess to fever of unknown origin.Here we report a case who initially presented as acute pancreatitis relapsing into chronic pancreatitis as an initial manifestation of disseminated tuberculosis
Indian J Tuberc 2008,55,214-216
Tubercular hepatic abscess-A rare presentation
A.P.Kansal,Vishal Chopra,Harpreet Singh and Urvinnder Pal Singh Hepatic tuberculosis is one of the rare forms of extra-pulmonary tuberculosis.The focal or nodular form presenting as tuberculoma or abscess is uncommon. Hepatic tuberculosis without involvement of lungs or other organs is even rarer. We report a rare case of primary tubercular liver abscess without involvement of any other organ of body.
[Indian J Tuberc 2008;55:217-220
[Indian J Tuberc 2008;55:157-161
Created on ... Nov 13, 2008/SMALL>
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