He appeared with fellow Rat Packers Dean Martin, Peter Lawford and Sammy Davis Jr. in the features "Ocean's Eleven" (1960) and "Sergeant's 3" (1962), as well as their Las Vegas shows. Bishop, whom Sinatra called the 'Speaker of the House', was one of the few who could razz 'Ol' Blue Eyes' and get away with it, announcing in one famous exchange to a crowd, "Mr Sinatra will now speak of some of the good things the Mafia has done." While he performed as the "straight man" during the famous "Rat Pack" performances in Las Vegas, he wrote much of the material that was performed on stage. Bishop was a regular on the TV quiz show "Keep Talking" from 1958 to 1960 and then starred for four seasons as late-night talk-show host Joey Barnes in his own sitcom, "The Joey Bishop Show" (NBC, 1961-64; CBS, 1964-65). That experience and his legendary ability to improvise helped him carve out a career as a real life talk-show host as well, working as a permanent guest host for Jack Paar in the 60s before going on to sub for Johnny Carson a record 207 times. In addition, he hosted his own ABC talk-show, also called "The Joey Bishop Show" (1967-69).

Among his other movies, Bishop acted in "The Naked and the Dead" (1958), "The Delta Force" (1986), as a Jewish-American hostage, and made a cameo appearance in his son Larry's "Mad Dog Time" (1996). He made his Broadway debut in 1981, stepping into "Sugar Babies", a musical hit reliving the hurly-burly days of burlesque that had spawned his career.

Joey Bishop’s wife Sylvia Ruzga died on September 20, 1999 after a long fight with lung cancer. The couple had one son, Larry. Today Joey lives with his beloves cat "Misty" in a cottage near Santa Monica /CA. Joey became the last surviving Rat Pack member with the death of Frank Sinatra in 1998.