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Take Route 12 South to I-190 South, to I-290 West, get off at Exit 18, and follow the Worcester Centrum Signs.
From the Northeast
Take Route I-495 South to I-290 West, get off at Exit 18, turn right, follow the signs to the Centrum.
Take Mass Pike (I-90) West, get off at Exit 10 Auburn, to I-290 East, then get off at Exit 16 East Central Street, turn left, and follow the signs to the Centrum.
Take Route 146 North to I-290 East, get off at Exit 16 East Central Street, turn left, follow the signs to the Centrum.
Take I-395 North to I-290 East, get off at Exit 16 East Central Street, turn left, and follow the signs to the Centrum.
Take Route 84 east to the Mass Pike. Get off at exit 10 Auburn to I-290 east , get off at exit 16 East Central Street, follow the signs to the Centrum.
Take the Mass Pike (I-90) East, to Exit 10 Auburn, follow that to I-290 East, get off at Exit 16 East Central Street, turn left, follow the signs to the Centrum.
Take route 122 South, remaining on Pleasant Street to the Centrum.
Take route 9 west into Worcester. For the Worcester Centrum Centreturn left onto Washington Square follow that to Worcester Center Boulevard, follow the signs to the Centrum.