The most powerful of all vampires is the Master. Trapped in a sort of dimensional prison, he was unable to enter our world, only able to act through his minions. With the help of these vampire followers, he was able to cross over to our world briefly by luring Buffy to his lair and biting her. Fortunately, Buffy wasn't dead and suprised the Master, impaling him. His minions, led by the Anointed One, tried to resurrect him using human sacrifice, but were foiled by Buffy, who then smashed the Master's bones to bits. The Master is gone forever, or at least for now.

An ancient and indestructable demon warrior, the judge once roamed the earth, laying waste to human civilization in the name of all that's evil. Since it was not possible to kill him with normal weapons, the only way to defeat him was to chop him up and separate the pieces from eachother. As a birthday gift to Drusilla, Spike orchestrated the Judge's resurrection, bringing the pieces back together. Once his parts were joined, the Judge was reanimated.

In the basement of a long-standing fraternity house in Sunnydale, a secret lurks. Machida, a huge snake-demon, arises each year and is appeased by the sacrifice of three young women. The women are lured there by members of the fraternity, who gain power and rewards from the demon for their evil work.

An ancient demon who lives by possessing the souls of dead or unconscious people, Eyghon comes to Sunnydale looking for its next victim. It seem that Giles is familiar with the demon, as is his friend Ethan. Back in college, they summoned the demon using an ancient ritual. Ethan and Giles both bore the mark of Eyghon-a tattoo-on their forearm.

Released when the seal that held her at bay was broken, this 500-year-old Incan mummy wreaks havoc on Sunnydale. Ampata can only continue to live if she periodically drains the life out of an unwitting victim with a deadly kiss.

After killing her entire family and visiting every conceivable mental torture on the young Drusilla, Angel turned her into a demon on the day she took the convent's holy vows. Completely insane, she rampaged through Europe, slaughtering victims mercilessly until she was almost killed herself by an angry crowd in Prague. Spike saved her and has been working to restore her to her full power. Cunning, deadly and deranged, Drusilla at full strength is a formidable enemy.

Imprisoned magically in an ancient book, Moloch is a demon fond of charming his victims into believing he is their friend, using them to do his bidding, then killing them. When the book was scanned into the Sunnydale High computer, Moloch escaped onto the internet.

Nicknamed as "Spike" because of his fondness for torturing his victims with railroad spikes, William the Bloody once hunted side-by-side with Angel. Since then, Angel has had a change of heart about killing humans. Spike on the other hand, will kill anyone who gets in his way. The Anointed One found that out the hard way when Spike became angry and hoisted him up into the sunlight, burning him to nothing.