I really love using knives, besides shotguns (which I am horrible with), knives are the best close range weapons. You can do in any character with 1 or 2 stabs. The Injun is the best character with knives, and he starts with seven. He also has lots of endurance, and can chase people down for awhile. If you happen to grab some knives, try to target little Sanchez's and Deaths'. They drop to the ground in one stab. People will learn your tricks though, and they will back up and cap you with a rifle. The Cheif is tough, but even he can only take a limited number of shots. Mostly you'll want to use knives in small congested spaces. But if for some reason you want to use knives otherwise, always use speed and try to strafe up in other characters faces. If someone starts to back up, don't chase, find the nearest room. The player will probably wander back around. If they don't find another target to stalk.