Starting in 2267 (five years after B5's fifth season), Crusade opens with the Shadows' former allies, the Drakh, mounting an attack against the Earth. Although the assault proves unsuccessful, it culminates with the Drakh releasing a biogenetic plague in the Earth's atmosphere that will wipe-out all life on the planet once its five-year incubation period has passed. The series will then follow the Rangers' quest to find a cure through the eyes of the crew of the Excalibur, a Deep Space exploration vessel assigned to search the remains of ancient worlds once occupied by the First Ones, in the hope of finding an antidote.
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