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Symptoms, maximize quality of life, reduce exacerbations, and prevent airway remodeling. The studies highlighted in this review article have shown that the addition of an LTRA to an inhaled corticosteroid is generally as effective at reducing exacerbations as adding an LABA. In have add-on the two largest and longest studies (6,7) in which the primary end point was as on exacerbations, the difference between either treatment was statistically and clinically nonsignificant. The addition of an LABA was consistently superior to an LTRA in improving lung function, .
While the latter treatment conferred antiinflammatory effects and attenuated AHR to a greater extent. In most of the studies, there were no significant differences in quality of life or symptoms, although in four out of nine studies, (7,51,53,55) the addition of an LABA was more favorable than that of an LTRA.
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