Piroxicam - pro and contra.

Piroxicam: uses Piroxicam is used to reduce pain, swelling, and joint stiffness from arthritis. Piroxicam is known as a nonsteroidal anti-inflammatory drug ( NSAID ) .

Piroxicam: how to use Read Medication Guide provided by your pharmacist before you start using Piroxicam and each time we get a refill. If we have any questions regarding information, consult your doctor or pharmacist.

Take Piroxicam by mouth usually once daily with a full glass of water ( 8 ounces or 240 milliliters ) , unless your doctor directs we otherwise. Don't lie down for at least 30 minutes after taking Piroxicam. If stomach upset occurs while taking Piroxicam, take it with food, milk, or an antacid.

Dosage is based on your medical condition and response to therapy. To reduce your risk of stomach bleeding and other side effects, take Piroxicam at lowest effective dose for the shortest possible time. Don't increase your dose, take it more frequently or take it for a longer time than prescribed.

In certain conditions ( e. g. , arthritis ) , it may take several weeks before your symptoms improve when Piroxicam is taken regularly. It may take several months before full benefits of Piroxicam take effect.

If we are taking Piroxicam on an " as needed " basis ( not on a regular schedule ) , remember that pain medications work best if they are used as first signs of pain occur. If we wait until the pain has significantly worsened, the medicine mayn't work as well.

Inform your doctor if your condition persists or worsens.

Piroxicam: other used This section contains uses of Piroxicam that aren't listed in the approved professional labeling for drug but that may be prescribed by your health care professional. Use Piroxicam for a condition that's listed in this section only if it has been so prescribed by your health care professional.

Piroxicam may also be used to treat other conditions including gouty arthritis, arthritis of spine, and muscle injuries.

Piroxicam: side effects Upset stomach, gas, constipation, diarrhea, nausea, vomiting, fatigue, dizziness, or headache may occur while use Piroxicam. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed Piroxicam because he or she has judged that the benefit to we is greater than risk of side effects. Many people using Piroxicam don't have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

Tell your doctor immediately if any of these rare but very serious side effects occur:

Piroxicam may rarely cause serious ( possibly fatal ) liver disease. If you notice any of following highly unlikely but very serious side effects, stop taking Piroxicam and consult your doctor or pharmacist immediately:

A very serious allergic reaction to Piroxicam is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

This isn't a complete list of possible side effects. If we notice other effects not listed above, contact your doctor or pharmacist.

Piroxicam: precautions Before taking Piroxicam, tell your doctor or pharmacist if you're allergic to it; or to aspirin or other NSAIDs ( e. g. , ibuprofen, naproxen, celecoxib ) ; or if we have any other allergies.

Piroxicam shouldn't be used if we have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if we have:

Before using Piroxicam, tell your doctor or pharmacist your medical history, especially of:

Before having surgery, tell your doctor or dentist that we are taking Piroxicam.

Piroxicam may make we dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

Piroxicam may make we more sensitive to sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Caution is advised when using Piroxicam in elderly because they may be more sensitive to its side effects, especially stomach bleeding and kidney effects.

Piroxicam should be used only when clearly needed during first 6 months of pregnancy. It's not recommended for use during last 3 months of pregnancy due to possible harm to an unborn baby and interference with normal labor/delivery. Discuss risks and benefits with your doctor.

Piroxicam passes into breast milk. Breast-feeding while using Piroxicam isn't recommended. Consult your doctor before breast-feeding.

Piroxicam: interactions Your healthcare professionals ( e. g. , doctor or pharmacist ) may already be aware of any possible drug interactions and may be monitoring you for it. Don't start, stop, or change the dosage of any medicine before checking with them first.

Piroxicam should not be used with the following medications because very serious interactions may occur while use Piroxicam:

If you're currently using any of these medications listed above, tell your doctor or pharmacist before starting Piroxicam.

Before using Piroxicam, tell your doctor or pharmacist of all prescription and nonprescription/herbal products we may use, especially of:

Check all prescription and nonprescription medicine labels carefully for other pain/fever drugs ( NSAIDs such as aspirin, celecoxib, ibuprofen ) . These drugs are similar to Piroxicam, so taking one of these drugs while also taking Piroxicam may increase your risk of side effects. However, if your doctor has prescribed low doses of aspirin to prevent heart attack or stroke ( usually at dosages of 81-325 milligrams a day ) , we should continue to take the aspirin. Daily use of NSAIDs ( e. g. , ibuprofen ) may decrease aspirin’s ability to prevent heart attack/stroke. Consult your doctor or pharmacist for more details and to discuss other possible treatments ( e. g. , acetaminophen ) for your pain/fever.

This document doesn't contain all possible interactions. Therefore, before using Piroxicam, tell your doctor or pharmacist of all the products we use. Keep a list of all your medications with you, and share list with your doctor and pharmacist.

Piroxicam with EU shipping

Low Vitamin D Levels Associated With An Increased Risk Of Peripheral Arterial Disease

Low levels of vitamin D may be associated with an increased risk for peripheral arterial disease ( PAD ) , researchers reported at American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2008.

Results of the study will also be simultaneously published in Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association.

PAD occurs when arteries in legs become narrowed or clogged with fatty deposits, reducing blood flow to legs. PAD affects about 8 million Americans and is associated with significant disease and death, according to American Heart Association's Heart Disease and Stroke Statistics - 2008 Update.

Vitamin D, or 25-hydroxyl vitamin D, is converted by the body to a hormone that makes bones stronger. Severe vitamin D deficiency can cause diseases such as rickets in children. Scientists are only beginning to explore relationship between 25-hydroxyl vitamin D and cardiovascular disease.

" In animals, vitamin D has anti-inflammatory activity, " said Michal Melamed, M. D. , M. H. S. , lead author of the study and assistant professor of Medicine and Epidemiology and Population Health at Albert Einstein College of Medicine in New York City.

" In addition, in mice, vitamin D is a regulator of one of hormone systems that affects blood pressure. The cells in blood vessels in body have receptors for vitamin D, so vitamin D may have direct effects on vessels, although this hasn't been fully worked out. '

To study whether there is a relationship of vitamin D with PAD, Melamed and colleagues analyzed data from a national survey measuring vitamin D levels in 4, 839 U. S. adults. Researchers in that survey had also documented ankle-brachial index, a PAD screening tool that measures blood flow to legs.

" We also measured other risk factors for peripheral arterial disease such as cholesterol levels, diabetes, blood pressure and inflammatory markers such as C-reactive protein, " Melamed said.

The researchers found that higher levels of vitamin D correlated with a lower prevalence of PAD. In participants with highest vitamin D levels -- more than 29. 2 nanogram per milliliter ( ng/mL ) -- only 3. 7 percent had PAD. Among those with lowest levels -- less than 17. 8 ng/mL -- 8. 1 percent had PAD.

" After adjusting for age, sex, race and co-existing health problems, we found adults in lowest vitamin D group had a 64 percent higher prevalence of PAD compared to those with highest vitamin D levels, " Melamed said. " For each 10 ng/mL lower vitamin D level, there was a 29 percent higher risk of peripheral arterial disease. '

This does not mean that vitamin D is having a protective effect itself, although this is one hypothesis. It is also possible that higher vitamin D levels may be a marker of other health practices, e. g. , eating a healthier diet or engaging in more physical activity - which could be related to sun exposure, though not necessarily, researchers said.

The findings need to be addressed in a large randomized clinical trial of vitamin D supplementation, Melamed said. This could be done with natural sources from food.

" Other vitamins have been thought to help prevent cardiovascular disease, such as vitamin E, which didn't pan out after being tested in a randomized clinical trial, " Melamed said. " Therefore, we'd not recommend people start taking vitamin D supplements without talking to their doctors. However, we recommend eating a balanced diet. People obtain vitamin D either through exposure to sun or from foods, especially fish and fortified milk and other fortified foods. '

The American Heart Association currently recommends that healthy people get adequate nutrients by eating a variety of foods in moderation, rather than by taking supplements. Food sources of vitamin D include fortified milk, salmon, sardines, cod liver oil and some fortified cereals. Vitamin or mineral supplements are not a substitute for a balanced, nutritious diet that limits excess calories, saturated fat, trans fat, sodium and dietary cholesterol. This dietary approach has been shown to reduce coronary heart disease risk in healthy people and those with coronary disease.

Statements and conclusions of abstract authors that are presented at American Heart Association/American Stroke Association scientific meetings are solely those of abstract authors and don't necessarily reflect association policy or position. The associations make no representation or warranty as to their accuracy or reliability.

American Heart Association http: //www. americanheart. org

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