The skin is often known as "the largest organ in the human body". This applies to exterior surface, as it covers the body, appearing to have the largest surface area of all the organs. Moreover, it applies to weight, as it weighs more than any single internal organ, accounting for about 15 percent of body weight. For the average adult human, the skin has a surface area of between 1.5-2.0 square metres, most of it is between 2-3 mm thick. The average square inch of skin holds 650 sweat glands, 20 blood vessels, 1000 melanocytes, and more than a thousand nerve endings. Skin is composed of the epidermis and the dermis. Below these layers lies the hypodermis(subcutaneous adipose layer), which is not usually classified as a layer of skin. The outermost epidermis is consists of stratified squamous epithelium with an underlying basement membrane. It contains no blood vessels, and is nourished by diffusion from the dermis. The main type of cells which make up the epidermis are keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum, granulosum, spinosum, basale. Cells are formed through mitosis at the innermost layers. They move up the strata changing shape and composition as they differentiate, inducing expression of new types of keratin genes. They eventually reach the corneum and become sloughed off (desquamation). This process is called keratinization and takes place within about 30 days. This layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out. The dermis can be split into the papillary and reticular layers. The papillary layer is outermost and extends into the dermis to supply it with vessels. It is composed of loosely arranged fibres. Papillary ridges make up the lines of the hands. The reticular layer is more dense and is continuous with the hypodermis. It contains the bulk of the structures (such as sweat glands). The reticular layer is composed of irregularly arranged fibres and resists stretching. As we age, our body undergoes various changes, and so does our skin. In our skin, we have tissues known as collagen and elastin. These tissues are mainly responsible for making our skin firm and stretchable. As we grow older, the amount of collagen and elastin in our skin naturally diminishes. As a result, our skin becomes less elastic and weaker, thus creating "wrinkles". Experts say that the amount of wrinkles that a person will develop through the years also depends on the genetic make up of this individual. However, smoking, sun exposure, dry skin, and repetitive facial expressions and mannerisms such as frowning, can all enhance the creation of wrinkles that may or may not be permanently present.
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