Under our skin

Skin has pigmentation, provided by melanocytes, which absorbs some of the potentially dangerous radiation in sunlight. It also contains DNA repair enzymes which reverse UV damage, and people who lack the genes for these enzymes suffer high rates of skin cancer. One form predominantly produced by UV light, malignant melanoma, is particularly invasive, causing it to spread quickly, and can often be deadly. Human skin pigmentation varies among populations in a striking manner. This has sometimes led to the classification of people on the basis of skin color. See the article on human skin color.

The skin on a person's face is seen by people that person interacts with. For some people, therefore, facial skin care is of particular importance, and they often use cosmetics to deal with the appearance of the face and condition of the skin, such as those for pore control and black head cleansing.

Skin is composed of the epidermis and the dermis. Below these layers lies the hypodermis(subcutaneous adipose layer), which is not usually classified as a layer of skin.

The outermost epidermis is consists of stratified squamous epithelium with an underlying basement membrane. It contains no blood vessels, and is nourished by diffusion from the dermis. The main type of cells which make up the epidermis are keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum, granulosum, spinosum, basale. Cells are formed through mitosis at the innermost layers. They move up the strata changing shape and composition as they differentiate, inducing expression of new types of keratin genes. They eventually reach the corneum and become sloughed off (desquamation). This process is called keratinization and takes place within about 30 days. This layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out.

Blood capillaries are found beneath the epidermis, and are linked to an arteriole and a venule. Arterial shunt vessels may bypass the network in ears, the nose and fingertips.

The hypodermis is not part of the skin, and lies below the dermis. Its purpose is to attach the skin to underlying bone and muscle as well as supplying it with blood vessels and nerves. It consists of loose connective tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (the hypodermis contains 50% of body fat). Fat serves as padding and insulation for the body.

The constantly peeling off dead cells of the epidermis mix with the secretions of the sweat and sebaceous glands and the dust found on the skin to form a filthy layer on its surface. If not washed away the dirt and dead skin slurry begins to decompose emitting a foul smell.

Terms interpreting

Acne

• An inflammatory disease of the sebaceous glands and hair follicles of the skin that is marked by the eruption of pimples or pustules, especially on the face.

Bacteria

• Microscopic unicellular prokaryotic organisms characterized by the lack of a membrane-bound nucleus and membrane-bound organelles.

Dermis

• The sensitive connective tissue layer of the skin located below the epidermis, containing nerve endings, sweat and sebaceous glands, and blood and lymph vessels.

Epidermis

• The outer, protective, nonvascular layer of the skin of vertebrates, covering the dermis.

Hypodermis

• A subcutaneous layer of loose connective tissue containing a varying number of fat cells.

Pimples

• A small swelling of the skin, usually caused by acne; a papule or pustule.

Ultraviolet radiation

• Invisible electromagnetic radiation between visible violet light and X rays.

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