Under our skin

In zootomy and dermatology, skin is an organ of the integumentary system composed of a layer of tissues that protect underlying muscles and organs. As the interface with the surroundings, it plays the most important role in protecting against pathogens. Its other main functions are insulation and temperature regulation, sensation and vitamin D and B synthesis.

Mammalian skin often contains hairs, which in sufficient density is called fur. The hair mainly serves to augment the insulation the skin provides, but can also serve as a secondary sexual characteristic or as camouflage. On some animals the skin is very hard and thick, and can be processed to create leather. Reptiles and fish have hard protective scales on their skin for protection, and birds have hard feathers, all made of tough β-keratins. Amphibian skin is not a strong barrier to passage of chemicals. A frog sitting in an anesthetic solution will quickly go to sleep.

The skin is often known as "the largest organ in the human body". This applies to exterior surface, as it covers the body, appearing to have the largest surface area of all the organs. Moreover, it applies to weight, as it weighs more than any single internal organ, accounting for about 15 percent of body weight. For the average adult human, the skin has a surface area of between 1.5-2.0 square metres, most of it is between 2-3 mm thick. The average square inch of skin holds 650 sweat glands, 20 blood vessels, 1000 melanocytes, and more than a thousand nerve endings.

The outermost epidermis is consists of stratified squamous epithelium with an underlying basement membrane. It contains no blood vessels, and is nourished by diffusion from the dermis. The main type of cells which make up the epidermis are keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum, granulosum, spinosum, basale. Cells are formed through mitosis at the innermost layers. They move up the strata changing shape and composition as they differentiate, inducing expression of new types of keratin genes. They eventually reach the corneum and become sloughed off (desquamation). This process is called keratinization and takes place within about 30 days. This layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out.

The dermis lies below the epidermis and contains a number of structures including blood vessels, nerves, hair follicles, smooth muscle, glands and lymphatic tissue. It consists of loose connective tissue otherwise called areolar connective tissue - collagen, elastin and reticular fibres are present. Erector muscles, attached between the hair papilla and epidermis, can contract, resulting in the hair fibre pulled upright and consequentially goose bumps.

The main cell types of skin are fibroblasts, adipocytes (fat storage) and macrophages. Sebaceous glands are exocrine glands which produce sebum, a mixture of lipids and waxy substances: lubrication, water-proofing, softening and antibactericidal actions are among the many functions of sebum. Sweat glands open up via a duct onto the skin by a pore.

The dermis can be split into the papillary and reticular layers. The papillary layer is outermost and extends into the dermis to supply it with vessels. It is composed of loosely arranged fibres. Papillary ridges make up the lines of the hands. The reticular layer is more dense and is continuous with the hypodermis. It contains the bulk of the structures (such as sweat glands). The reticular layer is composed of irregularly arranged fibres and resists stretching.

The skin supports its own ecosystems of microorganisms, including yeasts and bacteria, which cannot be removed by any amount of cleaning. In general these organisms keep one another in check and are part of a healthy skin. When the balance is disturbed, e.g., by antibiotics which kill bacteria, there may be an overgrowth and infection by yeasts. The skin is continuous with the inner epithelial lining of the body at the orifices, each of which supports its own complement of flora.

Smart skin care

Your skin is your armor, your shield from the elements. Yet when was the last time you really thought about what you need to do to take care of it? Throughout your life, genetic and environmental factors will cause a lot of wear and tear to your skin. But you are never too young or too old to start taking care of your skin.

The first step to taking care of your skin is preventing damage. Sun, wind, pollutants, and simply aging can degrade the condition of your skin. Common complaints include dry and itchy skin, wrinkles, sagging, color changes, and age spots. There are steps that you can take to keep you skin looking and feeling its best.

The most important way to care for your skin is to protect it from the damaging rays of the sun. Ultraviolet radiation damages the skin and can lead to wrinkles, premature aging, age spots, and cancer. Take extra precautions to make sure your skin is not exposed to the sun's rays. Use a natural sunscreen, or a moisturizer that contains sunscreen (at least SPF 15) everyday. Your skin does need some sunlight 10-15 minutes of direct exposure daily.

When you do use soap, try using a natural very mild soap that does not contain any dyes, parabens or perfumes. Follow up the bath with a moisturizing lotion, concentrating on problem dry areas. A good all natural moisturizer is one of the foundations for a healthy skin care regimen. Continue moisturizing throughout the day to keep skin healthy. Your hands and face are particularly susceptible to daily damage, and may need to be moisturized several times.

Acne, pimples, sunspots, age spots, wrinkles and other blemishes are skin conditions that plague people the world over. The global beauty industry already makes billions of dollars every year as women everywhere embark on quests to preserve (or achieve) a youthful, glowing appearance. Responding to this need, dermatologists, and other specialists continue to look for the best and safest possible treatments and formulations to combat skin ailments, the most common of which is acne.

Over the years, beauty experts and skin doctors have come up with a vast array products to treat and minimize wrinkles. Anti-wrinkle creams and ointments help reduce the appearance of wrinkles and prevent new ones from forming. These wrinkle ointments and anti-aging creams help a lot in restoring the skin's firmness and elasticity. In addition, these products contain anti-oxidants and retinol that not only aids in reducing wrinkles and fine lines on the skin, but also stimulates collagen production.

For people seeking solutions to severe damage that has already been done to the skin, there are a number of treatments available ranging from chemical peels and dermabrasion to the latest and technologically advanced, computerized laser resurfacing. However, many people looking for skin repair are hesitant to try chemical or laser peels due to the painful procedure and long recuperation period they have to undergo. The results of these procedures however, are fantastic.

There are a lot of skin care products in the market today. Unlike before when a normal bar of soap was used for skin cleansing, cosmetic companies are now producing a wide variety of skin care treatments that can address various skin concerns. However, there are cases when treatments need to be more aggressive, especially for those who have aging or blemished skin. Most, if not all, of the over-the-counter products are topical in nature, meaning it only affects the epidermis or the outer layer of the skin. Aging or blemished skin needs to be treated down to the root of the problem to see definite changes.

Definitions and terms

Acne

• An inflammatory disease of the sebaceous glands and hair follicles of the skin that is marked by the eruption of pimples or pustules, especially on the face.

Bacteria

• Microscopic unicellular prokaryotic organisms characterized by the lack of a membrane-bound nucleus and membrane-bound organelles.

Dermis

• The sensitive connective tissue layer of the skin located below the epidermis, containing nerve endings, sweat and sebaceous glands, and blood and lymph vessels.

Epidermis

• The outer, protective, nonvascular layer of the skin of vertebrates, covering the dermis.

Hypodermis

• A subcutaneous layer of loose connective tissue containing a varying number of fat cells.

Pimples

• A small swelling of the skin, usually caused by acne; a papule or pustule.

Ultraviolet radiation

• Invisible electromagnetic radiation between visible violet light and X rays.

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