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--> Why Metformin? Celebrating the Successes of the Orphan Drug Act. The Orphan Drug Act was signed into law 25 years ago. Find out what it is, what it's done, and what it means for the future of millions of people with rare diseases and conditions The advises from medical professionals.











on Arabic about Metformin لماذا؟ يحتفل اليتيم النجاحات التي تحققت في قانون المخدرات. اليتيم المخدرات قانون تم اقراره قبل 25 عاما. معرفة ما هي ، ما هو القيام به ، وما تعنيه بالنسبة لمستقبل الملايين من الناس مع الامراض النادرة وشروط

on Dutch about Waarom Metformine? Een feest voor de successen van de Orphan Drug Act. De Orphan Drug Act werd ondertekend in wet 25 jaar geleden. Zoek uit wat het is, hoe het is gedaan, en wat het betekent voor de toekomst van miljoenen mensen met zeldzame ziekten en de voorwaarden

on French about La metformine Pourquoi? Célébrer le succès de The Orphan Drug Act. The Orphan Drug Act a été signé en droit il ya 25 ans. En savoir ce qu'il est, ce qu'elle fait et ce que cela signifie pour l'avenir de millions de personnes avec des maladies rares et les conditions

on German about Metformin Warum? Wir feiern den Erfolgen der "Orphan Drug Act. Der Orphan Drug Act unterzeichnet wurde ins Gesetz 25 Jahren. Finden Sie heraus, was das ist, was es getan, und was es bedeutet, für die Zukunft von Millionen von Menschen mit seltenen Krankheiten und Bedingungen

on Greek about Γιατί μετφορμίνη; Γιορτάζοντας τις επιτυχίες του τα ορφανά φάρμακα πράξη. Τα ορφανά φάρμακα πράξη υπεγράφη σε νόμο πριν από 25 χρόνια. Μάθετε τι είναι, τι κάνει και τι σημαίνει για το μέλλον εκατομμυρίων ατόμων με σπάνιες παθήσεις και νόσους

on Italian about La metformina Perché? Celebrando i successi della Orphan Drug Act. Il Orphan Drug Act è stato firmato in legge 25 anni fa. Scoprire quello che è, ciò che è fatto, e ciò che significa per il futuro di milioni di persone con malattie rare e condizioni

on Japanese about メトホルミンはなぜですか？ オーファンドラッグの成功を記念して行動します。 オーファンドラッグ法が、法に署名し、 25年前です。 見つけてどのようなことは、どのように完了すると、およびそれがどういう意味なの未来のために何百万もの人々に希少疾患と条件

on Portuguese about Metformina Porquê? Comemorando o sucesso do Orphan Drug Act. O Orphan Drug Act foi assinado em lei há 25 anos atrás. Saiba o que é, o que é feito, eo que significa para o futuro de milhões de pessoas com doenças raras e condições

on Spanish about La metformina ¿Por qué? Celebrando los logros de la Ley de Medicamentos Huérfanos. La Ley de Medicamentos Huérfanos se firmó en ley hace 25 años. Averigüe qué es, qué se hace, y lo que significa para el futuro de millones de personas con enfermedades raras y condiciones

on English about Why Metformin? Celebrating the Successes of the Orphan Drug Act. The Orphan Drug Act was signed into law 25 years ago. Find out what it is, what it's done, and what it means for the future of millions of people with rare diseases and conditions



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Why Metformin?

 Why Metformin? FDA approved Metformin Celebrating the Successes of the Orphan Drug Act. The Orphan Drug Act was signed into law 25 years ago. Find out what it is, what it's done, and what it means for the future of millions of people with rare diseases and conditions The advises from medical professionals

Celebrating the Successes of the Orphan Drug Act. The Orphan Drug Act was signed into law 25 years ago. Find out what it is, what it's done, and what it means for the future of millions of people with rare diseases and conditions

Combating Antibiotic Resistance. Misuse and overuse of antibiotics have contributed to antibiotic resistance, a phenomenon that reduces or eliminates the effectiveness of antibiotics.

Making Sense of Vytorin Concerns. This article clarifies the results of a study that was published in the New England Journal of Medicine, and emphasizes the importance of continuing on prescribed cholesterol medications.

Why Metformin?

Why Metformin? FDA approved Metformin Celebrating the Successes of the Orphan Drug Act. The Orphan Drug Act was signed into law 25 years ago. Find out what it is, what it's done, and what it means for the future of millions of people with rare diseases and conditions The advises from medical professionals

Metformin: uses

Metformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes ( non-insulin-dependent diabetes ) . Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and decreased sexual ability. Metformin belongs to class of drugs known as biguanides. It works by helping to restore your body's proper response to insulin we naturally produce, and by decreasing amount of sugar that your liver makes and that your stomach/intestines absorb.

Metformin: how to use

Read Patient Information Leaflet if available from your pharmacist before we start using Metformin and each time we get a refill. If you have any questions, consult your doctor or pharmacist.

Take Metformin by mouth, usually twice a day with meals or as directed by your doctor. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

Carefully measure your dose with a special measuring device/spoon. Don't use a household spoon because we mayn't get the correct dose.

The dosage is based on your medical condition and response to therapy. Your doctor may direct we to take a low dose at first, gradually increasing dose to lower the chance of side effects such as upset stomach. Your doctor will adjust your dose based on your blood sugar levels to find best dose for you. Follow your doctor's directions carefully. The usual maximum dose for an adult is 2550 milligrams each day.

If we are already taking another anti-diabetic drug ( e. g. , chlorpropamide ) , follow your doctor's directions carefully for stopping/continuing the old drug and starting Metformin.

Use Metformin regularly in order to get most benefit from it. Remember to use it at same times each day.

Inform your doctor if your condition persists or worsens ( e. g. , blood sugar levels are high ) . It may take up to 2 weeks before full benefit of Metformin takes effect.

Metformin: side effects

See also Warning section.

Nausea, stomach upset, diarrhea, or a metallic taste in mouth may occur while use Metformin at first as your body adjusts to medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later ( after you're on same dose for several days or weeks ) , tell your doctor immediately. Stomach symptoms that occur after first days of your treatment may be a sign of lactic acidosis.

Remember that your doctor has prescribed Metformin because he or she has judged that the benefit to we is greater than risk of side effects. Many people using Metformin don't have serious side effects.

Metformin doesn't usually cause low blood sugar ( hypoglycemia ) . However, low blood sugar may occur while use Metformin, especially if you take other medications for diabetes, drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. Symptoms include cold sweat, blurred vision, dizziness, drowsiness, shaking, fast heartbeat, headache, fainting, tingling of hands/feet, and hunger. It's a good habit to carry glucose tablets or gel to treat low blood sugar. If you do not have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about reaction immediately. To help prevent low blood sugar, eat meals on a regular schedule, and don't skip meals. Check with your doctor or pharmacist to find out what we should do if we miss a meal.

Symptoms of high blood sugar ( hyperglycemia ) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor immediately. Your dosage may need to be increased.

A very serious allergic reaction to Metformin is rare. However, seek immediate medical attention if we notice any symptoms of a serious allergic reaction, including:

This isn't a complete list of possible side effects. If we notice other effects not listed above, contact your doctor or pharmacist.

Metformin: precautions

Before taking Metformin, tell your doctor or pharmacist if you are allergic to it; or if we have any other allergies.

Metformin should not be used if we have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if we have:

Before using Metformin, tell your doctor or pharmacist your medical history, especially of:

Before having surgery or any X-ray/scanning procedure using injectable iodinated contrast material, tell your doctor that you're taking Metformin. We will need to temporarily stop Metformin before time of your surgery/procedure. Consult your doctor for further instructions.

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Use caution while driving, using machinery, or taking part in any other activity that requires clear vision and alertness.

Limit alcohol while using Metformin to lower your risk of lactic acidosis.

It may be harder to control your blood sugar when your body is stressed ( e. g. , due to fever, infection, injury, or surgery ) . Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

Kidney function declines as we grow older. This medication is removed by kidneys. Therefore, elderly people may be a greater risk for side effects such as lactic acidosis or low blood sugar while using Metformin.

During pregnancy, Metformin should be used only when clearly needed. Discuss risks and benefits with your doctor. Your doctor may substitute insulin for Metformin during your pregnancy. Follow your doctor's instructions carefully.

Metformin can cause changes in menstrual cycle ( promote ovulation ) and increase risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.

It's not known whether Metformin passes into breast milk. Metformin could have undesirable effects on a nursing infant. Therefore, breast-feeding isn't recommended while using Metformin. Consult your doctor before breast-feeding.

Metformin: interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring we for them. Don't start, stop, or change the dosage of any medicine before checking with them first.

Before using Metformin, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

Many drugs can affect your blood sugar levels, making it more difficult to control your blood sugar. Before we start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor about results and of any symptoms of high or low blood sugar. ( See also Side Effects section. ) Your doctor may need to adjust your anti-diabetic medication, exercise program, or diet.

Some medications ( e. g. , beta blockers such as propranolol ) may mask fast/pounding heartbeat we would usually feel when your blood sugar level falls too low ( hypoglycemia ) . Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.

Check labels on nonprescription/herbal products carefully. Some products may contain sugar/alcohol and may affect blood sugars. Ask your doctor or pharmacist about using these products safely.

Cimetidine is a nonprescription drug that is commonly used to treat extra stomach acid. Because it may interact with Metformin, ask your pharmacist about other products to treat stomach acid.

This document does not contain all possible interactions. Therefore, before using Metformin, tell your doctor or pharmacist of all the products we use. Keep a list of all your medications with you, and share list with your doctor and pharmacist.

Metformin: overdose

If overdose of Metformin is suspected, contact your local poison control center or emergency room immediately. US residents can call US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Overdose can cause lactic acidosis and low blood sugar. Symptoms of overdose may include: rapid breathing, severe drowsiness, slow/irregular heartbeat.

Metformin: notes

Don't share Metformin with others.

You should attend a diabetes education program to learn more about diabetes and all important aspects of its treatment, including meals/diet, exercise, personal hygiene, medications, and getting regular eye/foot/medical exams.

Keep all medical appointments. Laboratory and/or medical tests ( e. g. , liver and kidney function tests, fasting blood glucose, hemoglobin A1c, complete blood counts ) should be performed periodically to check for side effects and monitor your response to therapy. Check your blood sugar levels regularly as directed.

Metformin: missed dose

If you miss a dose Metformin, take it as soon as we remember. If it's near time of the next dose, skip the missed dose and resume your usual dosing schedule. Don't double dose of Metformin to catch up.

Metformin: storage

Store Metformin at room temperature between 59-86 degrees F ( 15-30 degrees C ) away from light and moisture. Do not store Metformin in bathroom. Keep all medicines away from children and pets.

Properly discard Metformin when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Metformin: warning

Metformin can rarely cause a serious ( sometimes fatal ) condition called lactic acidosis. Stop taking Metformin and seek immediate medical attention if we develop any of following symptoms of lactic acidosis: unusual tiredness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, unusually slow/irregular heartbeat.

Lactic acidosis is more likely to occur in patients who have certain medical conditions, including kidney or liver disease, conditions that may cause a low oxygen blood level or poor circulation ( e. g. , severe congestive heart failure, recent heart attack, recent stroke ) , heavy alcohol use, a severe loss of body fluids ( dehydration ) , X-ray or scanning procedures that require an injectable iodinated contrast drug, recent surgery, or a serious infection. Tell your doctor immediately if any of these conditions occur or if we notice a big change in your overall health. We may need to stop taking Metformin temporarily. The elderly are also at higher risk, especially those older than 80 years who haven't had kidney tests. ( See also Side Effects and Precautions sections. )

FDA approved Metformin


The advises from medical professionals

Continuous Sivelestat Sodium Hydrate Infusion Averts Lipopolysaccharide-Induced Intestinal Paralysis And Hypotension In Conscious Guinea-Pigs. This study examined the effects of continuous administration of sivelestat sodium hydrate on guinea pigs induced with intestinal paralysis and hypotension. Findings suggest that sivelestat - a neutrophil elastase inhibitor- can effectively reduce intestinal dysfunction and attenuate hypotension. NE is a protease released in response to inflammation and is believed to trigger acute respiratory distress syndrome and ARDS-related lung injury.

Targacept Starts Phase 2b Clinical Trial Of TC-5214 As Augmentation Treatment In Major Depressive Disorder. Targacept, Inc., a clinical-stage biopharmaceutical company developing a new class of drugs known as NNR Therapeutics", today announced that it has initiated a Phase 2b clinical trial of TC-5214 as an augmentation therapy in subjects with Major Depressive Disorder. TC-5214 is a broad spectrum neuronal nicotinic receptor antagonist and represents a promising new mechanism in development for the treatment of MDD.

Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer And Associated Hepatitis B Virus. Jennerex, Inc., and its South Korean partner Green Cross Corp., announced that novel findings from a Phase I clinical trial of its first-in-class lead product JX-594 demonstrated that the product was well-tolerated and resulted in clear anti-cancer efficacy in patients with liver cancer. Three patients with advanced treatment-refractory hepatitis B virus -associated hepatocellular carcinoma were treated with JX-594.

Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme In Prostate Cancer Models. Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix, announced the presentation of positive pre-clinical animal efficacy data for its pegylated-rHuPH20 enzyme at the American Association for Cancer Research Translational Cancer Medicine meeting in Monterey, CA.

Hyperion Therapeutics Completes Enrollment In Phase 1/2 Clinical Trial In Patients With Urea Cycle Disorders. Hyperion Therapeutics, Inc. announced that it has completed patient enrollment in its Phase 1/2 clinical trial to evaluate the safety, tolerability and ammonia scavenging effects of HPN-100 versus BUPHENYL in patients with urea cycle disorders . The company plans to announce top-line results in the fourth quarter of this year.

Newly Published Study Results Showed That Two Mealtime Insulin Dosing Algorithms Were Effective For Patients With Type 2 Diabetes. Results from the "Adjust to Target in Type 2 Diabetes: Comparison of a Simple Algorithm to Carbohydrate Counting for Adjustment of Mealtime Insulin Glulisine" study, were published in the American Diabetes Association's medical journal, Diabetes Care.

NicOx Completes Enrollment Of Two Ambulatory Blood Pressure Measurement Studies For Naproxcinod In Hypertensive OA Patients. NicOx S.A. announced it has successfully completed the enrollment of 417 osteoarthritis patients with controlled hypertension in two clinical pharmacology studies in the United States, in line with previously announced timelines. These trials are designed to assess the blood pressure profile of naproxcinod, in comparison to ibuprofen and naproxen, using the Ambulatory Blood Pressure Monitoring technique.

Ekkyo Describes The First Benefits Of Controlled Hyperthermia In Humans In "Lasers In Surgery And Medicine". Ekkyo a photomedicine company, which develops first-in-class laser-based systems for skin scar prevention and reduction, announced the publication of a scientific article in Lasers in Surgery and Medicine reporting the results of a pilot study on cutaneous scar prevention by LASH.

No Reproductive Or Developmental Effects From Oral Exposure To Low Doses Of Bisphenol A. A new multigenerational reproductive toxicity study of dietary Bisphenol A in mice conducted by researchers at RTI International found no adverse effects of BPA on parents or offspring at dietary concentrations and doses comparable to those estimated for human exposure levels. These findings strongly support the conclusion that oral exposure to BPA is not harmful to children or adults at the low doses to which people are exposed.

Kidney Cancer Patients Find Hope In Everolimus. Everolimus, also called Certican, can stall progression of for patients with renal cell carcinoma who have experienced failure with other treatment regimens, according to an Article released on July 23, 3008 in The Lancet. Renal cell carcinoma, or metastatic kidney cancer, like other cancers, is believed to be caused by the abnormal functioning of signaling pathways in cells.

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Why Metformin? FDA approved Metformin Celebrating the Successes of the Orphan Drug Act. The Orphan Drug Act was signed into law 25 years ago. Find out what it is, what it's done, and what it means for the future of millions of people with rare diseases and conditions The advises from medical professionals

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