Obesity Linked To Increased Risk For Dementia

Obesity may increase adults' risk for having dementia, according to researchers at Johns Hopkins Bloomberg School of Public Health. Their analysis of published obesity and dementia prospective follow-up studies over past two decades shows a consistent relationship between two diseases. The results are published by The International Association for Study of Obesity in May, 2008 issue of Obesity Reviews .

" Our analysis of the data shows a clear association between obesity and an increased risk for dementia and several clinical subtypes of the disease, " said Youfa Wang, MD, PhD, senior author of study and associate professor with Bloomberg School's Center for Human Nutrition. " Subjects with a healthy body mass index ( BMI ) and waist circumference saw a decreased risk for dementia than their counterparts with an elevated BMI or waist circumference. " Wang adds, " Preventing or treating obesity at a younger age could play a major role in reducing number of dementia patients and those with other commonly associated illnesses such as Alzheimer's disease by up to 20 percent in United States. '

Lead researcher May A. Beydoun, along with Wang and H. A. Beydoun attribute these findings to a systematic review of 10 previously published studies that examined the relationships between dementia or its subtypes and various measures of body fat. Based on a pooled analysis of their findings from 7 of studies, baseline obesity compared to normal weight increased the risk of Alzheimer's disease by 80 percent on average. The team further concluded that being underweight also increases risk of dementia and its subtypes. The studies cited in meta-analysis were conducted in a number of countries, including the United States, Finland, Sweden and France, and contained middle-aged and older adults.

Previously published research defines dementia as not a single disorder, but a number of syndromes characterized by diverse behavioral, cognitive, and emotional impairments. The most common form is Alzheimer's disease, with an estimated 5 million adults living with disease in United States alone.

" Currently, Alzheimer's disease is eighth leading cause of death among the elderly population in United States. While more studies are needed to determine optimal weight and biological mechanisms associated with obesity and dementia, these findings could potentially decrease the number of people diagnosed with dementia and lead to an overall better quality of life, " said May A. Beydoun, a former postdoctoral research fellow at Johns Hopkins Bloomberg School of Public Health.

" Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis " was written by M. A. Beydoun, H. A. Beydoun and Y. Wang.

The research was funded by the Johns Hopkins Bloomberg School of Public Health.

Johns Hopkins Bloomberg School of Public Health 615 N. Wolfe St. , W1600 Baltimore, MD 21205 United States http: //www. jhsph. edu

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Before using Tenuate, tell your doctor or pharmacist your medical history, especially of:

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This document does not contain all possible interactions. Therefore, before using Tenuate, tell your doctor or pharmacist of all products we use. Keep a list of all your medications with you, and share list with your doctor and pharmacist.

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