Wrinkles should merely indicate where smiles have been.

Mark Twain

Mammalian skin often contains hairs, which in sufficient density is called fur. The hair mainly serves to augment the insulation the skin provides, but can also serve as a secondary sexual characteristic or as camouflage. On some animals the skin is very hard and thick, and can be processed to create leather. Reptiles and fish have hard protective scales on their skin for protection, and birds have hard feathers, all made of tough β-keratins. Amphibian skin is not a strong barrier to passage of chemicals. A frog sitting in an anesthetic solution will quickly go to sleep.

The skin is often known as "the largest organ in the human body". This applies to exterior surface, as it covers the body, appearing to have the largest surface area of all the organs. Moreover, it applies to weight, as it weighs more than any single internal organ, accounting for about 15 percent of body weight. For the average adult human, the skin has a surface area of between 1.5-2.0 square metres, most of it is between 2-3 mm thick. The average square inch of skin holds 650 sweat glands, 20 blood vessels, 1000 melanocytes, and more than a thousand nerve endings.

The outermost epidermis is consists of stratified squamous epithelium with an underlying basement membrane. It contains no blood vessels, and is nourished by diffusion from the dermis. The main type of cells which make up the epidermis are keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum, granulosum, spinosum, basale. Cells are formed through mitosis at the innermost layers. They move up the strata changing shape and composition as they differentiate, inducing expression of new types of keratin genes. They eventually reach the corneum and become sloughed off (desquamation). This process is called keratinization and takes place within about 30 days. This layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out.

The main cell types of skin are fibroblasts, adipocytes (fat storage) and macrophages. Sebaceous glands are exocrine glands which produce sebum, a mixture of lipids and waxy substances: lubrication, water-proofing, softening and antibactericidal actions are among the many functions of sebum. Sweat glands open up via a duct onto the skin by a pore.

The hypodermis is not part of the skin, and lies below the dermis. Its purpose is to attach the skin to underlying bone and muscle as well as supplying it with blood vessels and nerves. It consists of loose connective tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (the hypodermis contains 50% of body fat). Fat serves as padding and insulation for the body.

Skin can be dividided into thick and thin types. Thick skin is present on the soles of the feet and the palms of the hands. It has a larger stratum corneum with a higher keratin content. Thick skin does not grow hair; its purpose is to help grip. Thin skin is present on the bulk of the body and has a smaller stratum corneum and fewer papillae ridges. It has hair and is softer and more elastic. The characteristics of the skin, including sensory nerve density and the type of hair, vary with location on the body.

The constantly peeling off dead cells of the epidermis mix with the secretions of the sweat and sebaceous glands and the dust found on the skin to form a filthy layer on its surface. If not washed away the dirt and dead skin slurry begins to decompose emitting a foul smell.

Definition interpretation

Acne

• An inflammatory disease of the sebaceous glands and hair follicles of the skin that is marked by the eruption of pimples or pustules, especially on the face.

Bacteria

• Microscopic unicellular prokaryotic organisms characterized by the lack of a membrane-bound nucleus and membrane-bound organelles.

Dermis

• The sensitive connective tissue layer of the skin located below the epidermis, containing nerve endings, sweat and sebaceous glands, and blood and lymph vessels.

Epidermis

• The outer, protective, nonvascular layer of the skin of vertebrates, covering the dermis.

Hypodermis

• A subcutaneous layer of loose connective tissue containing a varying number of fat cells.

Pimples

• A small swelling of the skin, usually caused by acne; a papule or pustule.

Ultraviolet radiation

• Invisible electromagnetic radiation between visible violet light and X rays.

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