Relpax? For what?

uses of Relpax

Relpax is used to treat migraines when they occur. It helps to relieve headaches, pain, and other symptoms of migraines, including nausea, vomiting, and sensitivity to light/sound. Prompt treatment allows you to get back to your normal routine and may decrease your need for other pain medications. Relpax doesn't prevent future migraines or reduce how often we may get a migraine.

Relpax belongs to a group of drugs called " triptans. " Migraines are thought to occur when certain blood vessels in the brain become swollen ( dilated ) . Relpax works by helping blood vessels in brain to return to normal size. It may also block pain signals in the brain.

how to use of Relpax

Read Patient Information Leaflet available from your pharmacist before you start using Relpax and each time we get a refill. Ask your doctor or pharmacist if we have any questions.

Your dosage is based on your medical condition and response to treatment.

Take Relpax by mouth, with or without food, at first sign of a migraine as directed by your doctor. If there's no improvement in your symptoms, don't take any more doses of Relpax before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, we may take a second dose after 2 hours or as directed by your doctor. Don't take more than 2 doses in a 24-hour period. For the Canadian product: according to drug manufacturer, don't take more than 40 milligrams in a 24 hour period.

If you have certain conditions that increase your risk of heart disease and you have never taken Relpax before, you may need to be monitored for rare but serious side effects ( e. g. , chest pain ) when you take first dose. Your doctor may ask we to take first dose in office. See Precautions section for more information.

Tell your doctor if your condition doesn't improve or if it worsens.

side effects of Relpax

Tingling/numbness, nausea, weakness, drowsiness, or dizziness may occur while use Relpax. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed Relpax because he or she has judged that the benefit to you is greater than risk of side effects. Many people using Relpax don't have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

Pain/pressure/tightness in the chest/neck/jaw can occur shortly after using Relpax. These side effects are usually not serious. However, we mayn't be able to tell them apart from a rare but very serious reaction related to a lack of blood flow to heart, brain, or other parts of body. Therefore, seek immediate medical attention if you notice any of these unlikely side effects:

Relpax may rarely cause a very serious condition called serotonin syndrome. The risk increases when Relpax is taken with certain other drugs such as other " triptans " used to treat migraine headaches ( e. g. , sumatriptan, zolmitriptan ) , certain antidepressants including SSRIs ( e. g. , citalopram, fluoxetine, paroxetine ) and NSRIs ( e. g. , duloxetine, venlafaxine ) , or a certain drug to treat obesity ( sibutramine ) . Before taking Relpax, tell your doctor if we take any of these medications. Serotonin syndrome may be more likely when we start or increase the dose of any of these medications. Seek immediate medical attention if we develop some of following symptoms:

A very serious allergic reaction to Relpax is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

This isn't a complete list of possible side effects. If we notice other effects not listed above, contact your doctor or pharmacist.

precautions of Relpax

See also How to Use section.

Before taking Relpax, tell your doctor or pharmacist if we are allergic to it; or to other " triptan " migraine drugs ( e. g. , sumatriptan ) ; or if we have any other allergies.

Relpax shouldn't be used if we have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if we have:

Before using Relpax, tell your doctor or pharmacist your medical history, especially of:

Before using Relpax, tell your doctor or pharmacist if we have any condition that increases your risk of heart disease, including:

If we are at high risk for heart disease, your doctor may want to check your heart before prescribing Relpax.

Relpax may make we dizzy or drowsy. Use caution while driving, using machinery, or doing any other activity that requires alertness. Limit alcoholic beverages.

Caution is advised when using Relpax in the elderly because they may be more sensitive to its side effects, especially high blood pressure.

During pregnancy, Relpax should be used only when clearly needed. Discuss risks and benefits with your doctor.

Relpax passes into breast milk. Consult your doctor before breast-feeding.

interactions of Relpax

See also Side Effects section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Don't start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Relpax shouldn't be used with the following medication because a very serious interaction may occur while use Relpax:

Because very serious interactions may occur while use Relpax, Relpax shouldn't be used within 72 hours of drugs affecting liver enzymes that remove Relpax from your body ( e. g. , nefazodone, azole antifungals such as ketoconazole, itraconazole, macrolide antibiotics such as clarithromycin, erythromycin, troleandomycin, protease inhibitors such as nelfinavir, ritonavir ) .

Relpax shouldn't be used within 24 hours of the following medications because very serious interactions may occur:

If we are currently using any of above medications, tell your doctor or pharmacist before starting Relpax.

Before using Relpax, tell your doctor or pharmacist of all prescription and nonprescription products we may use, especially of:

Tell your doctor or pharmacist if we also take drugs that cause drowsiness such as: certain antihistamines ( e. g. , diphenhydramine ) , anti-seizure drugs ( e. g. , carbamazepine ) , medicine for sleep or anxiety ( e. g. , alprazolam, diazepam, zolpidem ) , muscle relaxants, narcotic pain relievers ( e. g. , codeine ) , psychiatric medicines ( e. g. , chlorpromazine, risperidone, amitriptyline, trazodone ) .

Check labels on all your medicines ( e. g. , cough-and-cold products ) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This document doesn't contain all possible interactions. Therefore, before using Relpax, tell your doctor or pharmacist of all products you use. Keep a list of all your medications with you, and share list with your doctor and pharmacist.

overdose of Relpax

If overdose of Relpax is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

notes of Relpax

Don't share Relpax with others.

Laboratory and/or medical tests ( e. g. , EKG ) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

missed dose of Relpax

Not applicable.

storage of Relpax

Store Relpax at room temperature at 77 degrees F ( 25 degrees C ) away from light and moisture. Brief storage between 59-86 degrees F ( 15-30 degrees C ) is permitted. Do not store Relpax in bathroom. Keep all medicines away from children and pets.

Properly discard Relpax when it's expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

FDA approved Relpax

Medtronic CONNECT Trial Concludes Enrollment

Medtronic, Inc. ( NYSE: MDT ) announced that patient enrollment in its CONNECTSM trial has concluded. The trial is assessing how the use of Medtronic CareLink� Network to remotely monitor patients with Concerto� cardiac resynchronization therapy-defibrillator ( CRT-D ) and Virtuoso� implantable cardioverter-defibrillator ( ICD ) effectively enables better patient care and reduces unnecessary healthcare costs. Principal investigator is George Crossley, M. D. , chief of electrophysiology at Baptist Hospital and Mid-State Cardiology in Nashville, Tenn. " Timely patient information delivered by wireless remote monitoring and CareAlert™ notifications is critical for physicians to effectively manage patients' cardiac conditions, " said Doctor Crossley. " Now that enrollment in the CONNECT trial is complete, we are looking forward to seeing data, which we believe will bear out that early indication of worsening heart conditions leads to early interventions, preventing costly hospitalizations. "

CONNECT ( Clinical Evaluation of Remote Notification to Reduce Time to Clinical Decision ) is a randomized, prospective study that includes 2, 000 patients at 141 centers across United States; patients will be followed for 15 months. The primary objective is to:

- Demonstrate that Medtronic's wireless remote management system reduces the time to clinical decision for arrhythmias ( abnormal heart rhythms ) , cardiovascular disease progression, and system issues compared to patients who receive only in-office care.

Secondary objectives include:

- A reduction in healthcare utilization, such as hospitalizations and visits to emergency room; and - Characterizing burden of in-office follow up visits for patients and their families, among other patient quality of life issues.

" Naturally, we'd expect that making clinical decisions earlier will help shift healthcare costs away from acute - and therefore more costly - interventions, " said David M. Steinhaus, M. D. , vice president and medical director of Cardiac Rhythm Disease Management business at Medtronic. " If physicians can receive early notification of condition changes through remote monitoring, they can adjust medications or change implanted device settings that may prevent disease progression to point where patients require action in an emergency department or other hospitalization. "

About Medtronic

Medtronic, Inc. , headquartered in Minneapolis, is the global leader in medical technology - alleviating pain, restoring health, and extending life for millions of people around the world.

Medtronic

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