# ANIMALKITS#

From: Subject: # ANIMALKITS# Date: Sat, 25 Oct 2003 08:05:11 -0500 MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_000_0000_01C39ACE.B6F0CA00"; type="multipart/alternative" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2800.1165 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C39ACE.B6F0CA00 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.animalkits.be/animalstyle.css A:active { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #ff0000; LINE-HEIGHT: = normal; FONT-STYLE: normal; FONT-FAMILY: Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A:link { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #0000ff; LINE-HEIGHT: = normal; FONT-STYLE: normal; FONT-FAMILY: Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } A:hover { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #0000ff; LINE-HEIGHT: = normal; FONT-STYLE: normal; FONT-FAMILY: Arial, Helvetica, sans-serif; = TEXT-DECORATION: underline } .text { FONT-WEIGHT: normal; FONT-SIZE: 14px; LINE-HEIGHT: normal; FONT-STYLE: = normal; FONT-FAMILY: Arial, Helvetica, sans-serif; TEXT-DECORATION: none } A:visited { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #0000ff; LINE-HEIGHT: = normal; FONT-STYLE: normal; FONT-FAMILY: Arial, Helvetica, sans-serif; = TEXT-DECORATION: none } ------=_NextPart_000_0000_01C39ACE.B6F0CA00 Content-Type: multipart/alternative; boundary="----=_NextPart_001_0003_01C39ACE.B6F5AC00" ------=_NextPart_001_0003_01C39ACE.B6F5AC00 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.animalkits.be/ # ANIMALKITS# ------=_NextPart_001_0003_01C39ACE.B6F5AC00 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.animalkits.be/up.htm Untitled = Document

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[= Register] =20 [Edit=20 Profile] [Edit Your=20 Preferences] [Search] [Private=20 Messages] [Memberslist= ] =20 [FAQ] = [Logout] =
Chemical Anarchy = Forum=20 Index =BB =BB Chemical=20 Anarchy Board =BB =BB interesting info on hormonal = disruptors=20

Author

interesting info on=20 hormonal disruptors

maximus

Joined: Dec 16, = 2001
Posts: = 439

Posted: = 2003-10-23=20 17:01

Widespread = Pollutants=20
with Endocrine-disrupting Effects

[background=20 information about some common EDCs]

Information is = regularly=20 added to this page.
If you have additions--new data on=20 chemicals, references,
corrections or things we missed, = etc.--=20
send information here

Persistent organohalogens=20

Compound(s) Hormone system affected Mechanism if = known=20
References
Benzenehexachloride (BHC) Thyroid =

Akhtar=20 et al. 1996

1,2-dibromoethane Reproductive =
Brittebo et=20 al. 1987

Chloroform
Reproductive
Brittebo et = al.=20 1987

Dioxins and furans

(in order of = antiestrogenic=20 potency : 2,3,7,8-tetrachlorodibenzo-p-dioxin >=20 2,3,7,8-tetrachlorodibenzofuran >=20 2,3,4,7,8-pentachlorodibenzo-furan >=20 1,2,3,7,9-pentachlorodibenzofuran >=20 1,3,6,8-tetrachlo-rodibenzofuran)
Estrogen
work as=20 anti-estrogen through binding with Ah receptor, which then = inhibits=20 estrogen receptor binding to estrogen response elements, = thereby=20 inhibiting estrogen action
Krishnan and Safe 1993 =

Klinge=20 et al. 1999

Octachlorostyrene Thyroid Sandan et al. = 2000=20
PBBs
Estrogen/ Thyroid

Bahn et al. 1980=20

Henderson et al. 1995

PCBs

(in order = of=20 antiestrogenic potency: 3,3' -pentachlorobiphenyl >=20 3,3,4,4,5,5'-hexachlorobiphenyl 3,3',4,4-tetrachlorobiphenyl = >=20 2,3,3',4,4',5'-hexa, 2,3,3',4,4'- and = 2,3,4,4',5-pentachlorobiphenyl=20 > Aroclors 1221, 1232. 1248, 1254, and 1260 were inactive = as=20 antiestrogens at the highest concentrations used in this = study (10-6=20 Ni)
Estrogen/androgen/Thyroid

Adverse outcomes = in=20 reproductive systems.
Inhibits estrogen binding to the = receptor;=20 works as anti-estrogen.

anti-androgenic via Ah = receptor=20 interaction

Korach et al. 1988

Zoeller et = al. 2000=20

Grey et al. 1999

PCB, hydroxylated Thyroid =
Binds=20 to thyroid hormone binding protein, but not to the thyroid = hormone=20 receptor.
Cheek et al. 1999

PBDEs Thyroid =
Interfere=20 with thyroxine (T4) binding with transthryetin
Ilonka et = al.=20 2000

Pentachlorophenol Thyroid
Reduces thyroid = hormone=20 possibly through a direct effect on the thyroid gland. =
Bear et=20 al. 1999

Gerhard et al. 1999

Food = Antioxidant=20

Compound Hormone system affected Mechanism =
References=20
Butylated hydroxyanisole (BHA)
Estrogen
Inhibits = binding=20 to the estrogen receptor.
Jobling et al. 1995=20

Pesticide (for information organized by=20 pesticide class)

Compound Hormone system affected = Mechanism=20
References
Acetochlor Thyroid (decrease of thyroid = hormone=20 levels, increase in TSH)

Hurley et al. 1998 =

Alachlor=20 Thyroid (decrease of thyroid hormone levels, increase in = TSH)=20

Wilson et al. 1996

Aldrin Estrogen
Binds = to=20 estrogen receptors; competes with estradiol.
Jorgenson = 2001=20

Allethrin, d-trans Estrogen

Go et al. 1999=20

Amitrol Thyroid
Thyroid peroxidase inhibitors; = inhibits=20 thyroid hormone synthesis.
Hurley et al. 1998 =

Atrazine=20 Neuroendocrine-pituitary (depression of LH surge), = testosterone=20 metabolism.
Inhibits ligand binding to androgen and = estrogen=20 receptors.
Danzo 1997

Carbaryl Estrogen and = progesterone=20

Klotz et al. 1997

Chlofentezine Thyroid =
Enhances=20 secretion of thyroid hormone.
Hurley et al. 1998=20

Chlordane Testosterone and progesterone =

Willingham=20 et al. 2000

Cypermethrin Disruption of reproductive = function=20

Moore and Waring 2001

DDT Estrogen
DDT = and=20 related compounds act in a number of ways to disrupt = endocrine=20 function by binding with the estrogen receptor, including = estrogen=20 mimickry and antagonism, altering the pattern of synthesis = or=20 metabolism of hormones, and (4) modifying hormone receptor = levels=20
Soto et al. 1994

Lascombe et al. 2000 =

Kupfer et=20 al. 1980

Rajapakse et al. 2001

DDT = Metabolite,=20 p,p'-DDE Androgen
Inhibits androgen binding to the = androgen=20 receptor, androgen-induced transcriptional activity, and = androgen=20 action in developing, pubertal and adult male rats. =
Kelce 1995=20

Dicofol (Kelthane) Estrogen
Vinggaard et al. = 1999=20

Dieldrin Estrogen
Binds to estrogen = receptor;competes=20 with estradiol.
Arnold et al. 1997

Soto et al. = 1994=20

Jorgenson 2001

Endosulfan Estrogen =

Soto et=20 al. 1994

Soto et al. 1995

Ethylene thiourea = Thyroid=20
Thyroid peroxidase inhibitor.
Hurley et al. 1998=20

Fenarimol Estrogen
Estrogen receptor agonist.=20
Vinggaard et al. 1999

Fenbuconazole Thyroid =
Enhances=20 secretion of thyroid hormone.
Hurley et al. 1998=20

Fenitrothion Antiandrogen
Competitive androgen = receptor=20 antagonist.
Tamura et al. 2001

Fenvalerate = Estrogen=20

Go et al. 1999

Fipronil Thyroid
Enhances = secretion of thyroid hormone.
Hurley et al. 1998=20

Heptachlor Thyroid

Akhtar et al. 1996 =

Reuber=20 1987

Heptachlor-epoxide Thyroid/Reproductive =
Metabolite=20 of heptachlor
Reuber 1987

Iprodione = Inhibition of=20 testosterone synthesis

Benhamed 1996

Karate = Thyroid=20
A decrease of thyroid hormone in serum; direct effect on = the=20 thyroid gland?
Akhtar et al. 1996

Kepone = (Chlordecone)=20 Estrogen
Displays androgen and estrogen receptor-binding = affinities.
Waller et al. 1996

Soto et al. 1994=20

McLachlan(ed)

Ketoconazole Effects on = reproductive=20 systems

Marty et al. 1999

Marty et al. 2001=20

Lindane (Hexachlorocyclohexane) Estrogen/Androgen=20
Inhibits ligand binding to androgen and estrogen = receptors.=20
Danzo 1997

Linuron Androgen
Androgen = receptor=20 antagonist.
Waller et al. 1996

Lambright et al. = 2000=20

Grey et al. 1999

Malathion Thyroid =
Significant=20 decrease of thyroid hormone in serum, with perhaps a direct = effect=20 on the thyroid gland.
Akhtar et al. 1996 =

Mancozeb=20 Thyroid
Thyroid peroxidase inhibitors.
Hurley et al. = 1998=20

Maneb Thyroid
The metabolite ethylenthiourea = inhibits=20 thyroid hormone synthesis.

Toppari et al. 1995=20

Methomyl Thyroid

Porter et al. 1993 =

Klotz et=20 al. 1997

Methoxychlor Estrogen
Through = mechanisms other=20 than receptor antagonism. Precise mechanism still unclear.=20
Pickford and Morris 1999

Metribuzin Thyroid=20

Porter et al. 1993

Mirex Antiandrogenic = activity;=20 inhibits production of LH. Potentially thyroid.

Chen = et al.=20 1986

Chernoff et al. 1976

Nitrofen Thyroid=20
Structural similarities to the thyroid hormones; = nitrofen or its=20 metabolite may have thyroid hormone activities.
Stevens = and=20 Summer 1991

Nonachlor, trans- Estrogen
Estrogen = receptor=20 agonist?
Willingham et al. 2000

Oxychlordane=20 Reproductive

Guillette et al. 1999 =

Pendimethalin=20 Thyroid
Enhances secretion of thyroid hormone. =
Hurley et al.=20 1998

Pentachloronitrobenzene Thyroid
Enhances = secretion=20 of thyroid hormone.
Hurley et al. 1998 =

Permethrin=20 Estrogenic

Go et al. 1999

Procymidone = Androgen=20
Androgen receptor antagonist.
Ostby et al. 1999 =

Grey=20 et al. 1999

Prodiamine Thyroid
Enhances = secretion of=20 thyroid hormone.
Hurley et al. 1998

Pyrimethanil = Thyroid=20
Enhances secretion of thyroid hormone.
Hurley et al. = 1998=20

Sumithrin Androgen

Go et al. 1999 =

Tarstar=20 Thyroid
A decrease of thyroid hormone in serum; direct = effect on=20 the thyroid gland?
Akhtar et al. 1996

Thiazopyr = Thyroid=20
Enhances secretion of thyroid hormone.
Hurley et al. = 1998=20

Thiram Neuroendocrine-pituitary (depression of LH = surge),=20 thyroid (decrease of T4, increase of TSH)

Stoker et = al. 1993=20

Toxaphene Estrogen/ Thyroid

Soto et al. 1994 =

Triadimefon Estrogen
Estrogen receptor agonist.=20
Vinggaard et al. 1999

Triadimenol Estrogen =
Estrogen=20 receptor agonist
Vinggaard et al. 1999 =

Tributyltin=20 Reproductive

Horiguchi et al. 2000 =

Trifluralin=20 Reproductive/ Metabolic

Rawlings et al. 1998=20

Vinclozolin Androgen
Anti-androgenic. (Competes = with=20 androgens for the androgen receptor (AR), inhibits AR-DNA = binding,=20 and alters androgen-dependent gene expression.)
Soto et = al. 1994=20

Soto et al. 1995

Kelce et al. 1994 =

Grey et=20 al. 1999

Zineb Thyroid
The metabolite = ethylenthiourea=20 inhibits thyroid hormone synthesis.
Toppari et al. 1995=20

Ziram Thyroid
Inhibits the iodide peroxidase. = Structural=20 similarities between ziram and thiram; ziram can be = metabolized to=20 thiram in the environment.
Marinovich et al. 1997=20

Phthalate

Compound Hormones affected = Mechanism=20
References
Butyl benzyl phthalate (BBP) Estrogen=20
Inhibits binding to the estrogen receptor
Jobling et = al.=20 1995

Di-n-butyl phthalate (DBP) Estrogen =

Androgen=20
Inhibits binding to the estrogen receptor.=20

anti-androgenic
Jobling et al. 1995 =

Harris et=20 al. 1997

Grey et al. 1999

Di-ethylhexyl = phthalate=20 (DEHP) Estrogen

Androgen
Inhibits binding to the = estrogen receptor.

anti-androgenic
Jobling et = al. 1995=20

Harris et al. 1997

Moore et al. 2001 =

Grey et=20 al. 1999

Diethyl Phthalate (DEP) Estrogen =

Harris et=20 al. 1997

Other Compounds

Compound = Hormones=20 affected Mechanism
References
Benzophenone =
Estrogen=20
Binds weakly to estrogen receptors, roles of its = metabolite=20 remain to be clarified.
Schlumpf et al. 2001 =

Bisphenol A=20
Estrogen
Estrogenic; binds to estrogen receptor =
Fisher=20 et al. 1999

Anderson et al. 1999

Rajapakse = et al.=20 2001

Bisphenol F
Estrogen
Estrogenic; b inds = to=20 estrogen receptor
Perez et al. 1998 =

Benzo(a)pyrene=20
Androgen
anti-androgenic
Thomas 1990 =

Carbendazim=20
Reproductive

Gray et al. 1990

Ethane = Dimethane=20 Sulphonate
Reproductive

Gray et al. 1999=20

Perfluorooctane sulfonate
(PFOS)
Thyroid,=20 reproductive
suppression of T3,T4; mechanism unknown =
3M data=20

Nonylphenol, octylphenol
Estrogen
Estrogen = receptor=20 agonists; reduces estradiol binding to the estrogen = receptor.=20
Soto et al. 1991

Soto et al. 1995

Danzo = 1997=20

Lascombe et al. 2000

Rajapakse et al. 2001=20

Resorcinol Thyroid
Lindsay et al. 1989=20
Styrene dimers and trimers
Estrogen
Estrogen = receptor=20 agonists
Ohyama et al. 2001

Metals =

Compound=20 Hormones affected Mechanism
References
Arsenic=20 Glucocorticoid
Selective inhibition of DNA transcription = normally stimulated by the glucocorticoid-GR complex. =
Kaltreider=20 et al. 2001

Cadmium Estrogenic
Activates = estrogen=20 receptor through an interaction with the hormone-binding = domain of=20 the receptor.
Stoica et al. 2000

Johnson et al. = 2003=20

Lead Reproductive

Telisman et al. 2000 =

Hanas=20 et al. 1999

Mercury Reproductive/ Thyroid =

Facemire=20 et al. 1995

lots of things affecting thyroid=20

3D"Email

=20 = =20 =20

BrooklynJuice

Joined: Apr 02, = 2002
Posts: = 5156
From: Cloned Elf = on Smart=20 Drugs

Posted: = 2003-10-23=20 18:22

how about = anybody use=20 airlines alot?

lots of radiation up in those puppies =

thyroid is greatly affected by rad

=20 = =20 =20

Animal

Joined: Dec 03, = 2001
Posts: = 8172
From: The darkest = depths of=20 Hell.

Posted: = 2003-10-23=20 20:17

And those = airlines are=20 festering mold and germ breeding wonderlands. Recycled air = going=20 through filters they never change. Thanks to them I'm sick = right now=20 and I haven't been sick for a year!

As for the = estrogen in=20 EVERYTHING I'm sure the gov wants it as it helps make people = fat and=20 less aggressive to their brainwashing. Think about it. What = better=20 enemy to have than fat people who can't think and can't = fight! Duh=20 HA fucking UH!

=20 = =20 =20

instynct999

Joined: Feb 27, = 2002
Posts: = 4521

Posted: = 2003-10-23=20 20:20

A dead on = the nose again=20

shit , more people get sick coming off a plane than = anything=20

boost those immune compounds pre- and post=20 flight!!

3D"Email

=20 = =20 =20

jtest28

Joined: Feb 19, = 2002
Posts: = 454

Posted: = 2003-10-23=20 20:36

Quote:

As for the estrogen in EVERYTHING I'm = sure=20 the gov wants it as it helps make people fat and = less=20 aggressive to their brainwashing. Think about it. = What=20 better enemy to have than fat people who can't think = and=20 can't fight! Duh HA fucking UH! =

True Animal.=20 I have been saying for years thats the only reason = "steroids" (I=20 like to just call it male hormones) got banned. Thats why = there have=20 been cases where the government tried to send even DOCTORS = to prison=20 for trying to prescribe HRT for men with lower than usual = test=20 levels. I also find it interesting how in the medical books = it tells=20 what the average man's testosterone level is but what it = won't tell=20 you is that it is the average MODERN man's test level! Not = what men=20 are really supposed to be having! Just because it is average = doesn't=20 mean it is normal.) I can't remember where I read it but I = read=20 somewhere that men in the 1950's had a level between = 750-1200ng/dl.=20 And now you read that the average man's level is 330 and up. = Is it=20 true a doc isn't allowed to prescribe test unless the level = is below=20 330? It wouldn't surprise me. If this is the case this is = tantamount=20 to castration for American men... =
_________________
"The government will always find a marvelous = reason for=20 taking your liberty away from you." - Al

=20 = =20 =20

instynct999

Joined: Feb 27, = 2002
Posts: = 4521

Posted: = 2003-10-23=20 20:38

actually it = is even=20 lower than 330, mpre like 200 i believe if memory = serves

3D"Email

=20 = =20 =20

jtest28

Joined: Feb 19, = 2002
Posts: = 454

Posted: = 2003-10-23=20 20:40

Quote:

On 2003-10-23 20:38, instynct999 = wrote:=20
actually it is even lower than 330, mpre like = 200 i=20 believe if memory serves =

Holy shit...=20

Hey you no what will be really fucked up? When the = day comes=20 when women can get test implants or shots so they can have a = higher=20 sex drive yet men won't be allowed to.=20
_________________
"The government = will always=20 find a marvelous reason for taking your liberty away from = you." - Al

=20 = =20 =20

Animal

Joined: Dec 03, = 2001
Posts: = 8172
From: The darkest = depths of=20 Hell.

Posted: = 2003-10-23=20 20:46

Yea, we = might have roid=20 rage which has NEVER EVER been proven while ho's get = hormones while=20 they want bitchMS to be a medical condition.

A = cuntry run by=20 cunts and bitches and the assfucks who cater to them for use = of a=20 vagina!

This place is disgusting.

=20 = =20 =20

bigeasy911

Joined: Dec 07, = 2001
Posts: = 91

Posted: = 2003-10-24=20 00:10

yep very low = 200's or=20 below. LAst test I had "normal" range was 249-850 or 900. = 249 yeh if=20 I was 90. unfucking believable.
_________________
Big = E

= =20 =20

=20

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