Illinois State Route 100 is a north-south highway in Calhoun County. It is the main north-south highway of the county. IL St Rt 100 passes through the following towns in Calhoun County. Hardin
Michael
Kampsville
IL St Rt 100 is not multi-plexed in Calhoun County. IL St Rt 100 intersects the following highways in Calhoun County. Illinois State Route 96, at Kampsville.