U.S. Federal Route 59 is the main north-south highway in Central Shelby County. This connects Harlan to Denison and Interstate 80. U.S. Rt. 59 intersects the following towns in Shelby County. Corley Harlan Defiance U.S. Rt. 59 is not multi-plexed in Shelby County. U.S. Rt. 59 intersects the following highways in Shelby County. Iowa State Route 44, at Harlan. Iowa State Route 37, near Earling.