U.S. Federal Route 61 from Muscatine to the Scott/Muscatine County line ia mostly a four-lane divided highway. South of Muscatine is become a two-lane surface route. At Muscatine, U.S. Rt. 61 by-passes the town to the north and west. U.S. Rt. 61 passes through the following town in Muscatine County. Muscatine
U.S. Rt. 61 is multi-plexed in Muscatine County. Iowa State Route 22, around Muscatine.