U.S. Federal Route 6 is the main east-west surface highway in Northern Muscatine County. U.S. Rt. 6 passes through the following towns in Muscatine County. Wilton Atalissa West Liberty U.S. Rt. 6 is multi-plexed in Muscatine County. Iowa State Route 38, from the Cedar/Muscatine County Line to near Wilton.
U.S. Rt. 6 intersects the following highways in Muscatine County. Iowa State Route 927, at Wilton.