Iowa State Route 22 runs east-west in Scott County. This highway runs along the Mississippi River in the southwestern portion of the county. It is a alternative to U.S. Rt. 61 to the north. IA St Rt 22 passes through the following towns in Scott County. Davenport Buffalo IA St Rt 22 is not multi-plexed in Scott County. IA St Rt 22 intersects the following highways in Scott County. U.S. Rt. 61, at Davenport.