U.S. Federal Route 40 runs east-west across Southern Cumberland County. This runs along the southern part of the Interstate 70 corridor. U.S. Rt. 40 passes through the following towns in Cumberland County. Woodbury Greenup
U.S. Rt. 40 is not multi-plexed in Cumberland County. U.S. Rt. 40 intersects the following highway in Cumberland County. Illinois State Route 130, at Greenup.