U.S. Federal Route 45 is the main north-south highway in Central Wayne County. U.S. Rt. 45 passes thorugh the following towns in Wayne County. Cisne Jeffersonville (Geff) Fairfield
A Wayne County mile marker. SB U.S. Rt. 45/EB IL St Rt 15 in Fairfield. A junction marker on SB U.S. Rt. 45/EB IL St Rt 15. SB U.S. Rt. 45 south of Fairfield. A BGS on EB I-64.