U.S. Federal Route 50 is a main east-west surface route in Lawrence County. This highway was by-passed around Lawrenceville. West of Lawrenceville the old alignment is Illinois State Route 250. In Lawrenceville, it is BUSN. U.S. Rt. 50. East of Lawrenceville to the Indiana State Line, U.S. Rt. 50 is a expressway. U.S. Rt. 50 does not pass through any towns in Lawrence County. U.S. Rt. 50 is multi-plexed in Lawrence County. Illinois State Route 250, from the Richland/Lawrence County Line to near Sumner.
U.S. Rt. 50 intersects the following highways in Lawrence County. Illinois State Route 250, near Sumner.
Branches of U.S. Rt. 50 in Lawrence County. A Lawrence County mile marker. A junction sign near Sumner. EB U.S. Rt. 50 on the westside of Lawrence. East of Lawrenceville, U.S. Rt. 50 is a expressway with the speed at 65 M.P.H. Various milage signs east of Lawrenceville. A junction marker on SB IL St Rt 33. A BGS on SB IL St Rt 33. EB U.S. Rt. 50 at the Illinois/Indiana State Line.