La Salle County Highway 21 is a east-west highway in East-Central La Salle County. This runs between Illinois State Route 23 and Illinois State Route 71. It provides another crossing over the Fox River. LSCH 21 passes through the following town in La Salle County. Wedron LSCH 21 intersects the following highways in La Salle County. Illinois State Route 71, near Danway. La Salle County Highway 11, at Wedron. La Salle County Highway 2, at Wedron. Illinois State Route 23, near Wedron.
WB LSCH 21 east of Wedron. WB LSCH 21 at Wedron. EB LSCH 21 at IL St Rt 23.
