Mississippi State Route 346 is a east-west highway in Northwestern Pontotoc County. It runs from Mississippi State Route 15, near Ecru, to near the Holly Springs National Forest. MS St Rt 346 does not pass through any towns in Pontotoc County. MS St Rt 346 is not multi-plexed in Pontotoc County. MS St Rt 346 intersects the following highways in Pontotoc County. Mississippi State Route 15, near Ecru. Mississippi State Route 355, near Thaxton.
